Plasma renin activity predicts blood pressure responses to beta-blocker and thiazide diuretic as monotherapy and add-on therapy for hypertension.
Plasma renin activity predicts blood pressure responses to beta-blocker and thiazide diuretic as monotherapy and add-on therapy for hypertension.
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DOI：
10.1038/ajh.2010.98
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发表时间：
2010-09
影响因子：
3.2
通讯作者：
Bailey, Kent R.
中科院分区：
文献类型：
--
作者：
Turner, Stephen T.;Schwartz, Gary L.;Chapman, Arlene B.;Beitelshees, Amber L.;Gums, John G.;Cooper-DeHoff, Rhonda M.;Boerwinkle, Eric;Johnson, Julie A.;Bailey, Kent R.
关键词：
年龄和种族分类或肾素谱已被推荐用于预测β受体阻滞剂或噻嗪类利尿剂单药治疗的血压反应。这些或其他特征是否可以预测药物作为附加治疗时的血压反应尚不确定。我们评估了363名年龄≤65岁的男性和女性原发性高血压患者的血压反应预测因素（152名黑人，211名白人），其中86例（24%）未接受治疗，其中277例（76%）在随机分配至阿替洛尔后添加氢氯噻嗪之前停用既往降压药物（N = 180）或氢氯噻嗪，然后添加阿替洛尔（N = 183）。通过每次给药前后的家庭血压平均值确定反应。将种族、年龄、血浆肾素活性和其他特征（包括治疗前血压水平）纳入线性回归模型，以量化其对血压反应预测的贡献。血浆肾素活性和治疗前血压水平一致地有助于预测作为单药和添加治疗的每种药物的收缩和舒张反应。较高的血浆肾素活性始终与阿替洛尔的血压反应较大和氢氯噻嗪的反应较小相关。血浆肾素活性的预测作用在统计学上与种族、年龄和其他特征无关。血浆肾素活性和治疗前血压水平可预测年龄≤65岁的男性和女性对阿替洛尔和氢氯噻嗪单药治疗和添加治疗的血压反应。
Age and race categories or renin profiling have been recommended to predict blood pressure responses to monotherapy with a β-blocker or thiazide diuretic. Whether these or other characteristics predict blood pressure responses when the drugs are administered as add-on therapy is uncertain. We evaluated predictors of blood pressure response in 363 men and women ≤65 years of age with primary hypertension (152 blacks, 211 whites), 86 of whom (24%) were untreated and 277 of whom (76%) were withdrawn from previous antihypertensive drugs before randomization to either atenolol followed by addition of hydrochlorothiazide (N = 180) or hydrochlorothiazide followed by addition of atenolol (N = 183). Responses were determined by home blood pressure averages before and after each drug administration. Race, age, plasma renin activity, and other characteristics including pretreatment blood pressure levels were incorporated into linear regression models to quantify their contributions to prediction of blood pressure responses. Plasma renin activity and pretreatment blood pressure level consistently contributed to prediction of systolic and diastolic responses to each drug administered as mono- and as add-on therapy. Higher plasma renin activity was consistently associated with greater blood pressure responses to atenolol and lesser responses to hydrochlorothiazide. The predictive effects of plasma renin activity were statistically independent of race, age, and other characteristics. Plasma renin activity and pretreatment blood pressure level predict blood pressure responses to atenolol and hydrochlorothiazide administered as mono- and as add-on therapy in men and women ≤65 years of age.
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影响因子：
4.8
作者：
Johnson, Julie A.;Boerwinkle, Eric;Zineh, Issain;Chapman, Arlene B.;Bailey, Kent;Cooper-DeHoff, Rhonda M.;Gums, John;Curry, R. Whit;Gong, Yan;Beitelshees, Amber L.;Schwartz, Gary;Turner, Stephen T.
通讯作者：
Turner, Stephen T.
影响因子：
3.2
作者：
Canzanello, Vincent J.;Baranco-Pryor, Evelyn;Chapman, Arlene B.
通讯作者：
Chapman, Arlene B.
影响因子：
5.9
作者：
FREIS, ED;MATERSON, BJ;FLAMENBAUM, W
通讯作者：
FLAMENBAUM, W
影响因子：
5.9
作者：
CASE, DB;WALLACE, JM;LARAGH, JH
通讯作者：
LARAGH, JH
影响因子：
158.5
作者：
CASE, DB;WALLACE, JM;LARAGH, JH
通讯作者：
LARAGH, JH