Antimicrobial Rubber Nanocapsule-Based Iodophor Promotes Wound Healing
Antimicrobial Rubber Nanocapsule-Based Iodophor Promotes Wound Healing
复制标题
基于抗菌橡胶纳米胶囊的碘伏促进伤口愈合
DOI：
10.31635/ccschem.020.201900101
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发表时间：
2020-01-01
期刊：
影响因子：
11.2
通讯作者：
Wang, Yapei
中科院分区：
文献类型：
--
作者：
Li, Ruiting;Wang, Zhen;Wang, Yapei
自上世纪以来，聚维酮碘一直引领全球临床消毒剂市场，但对其对人体组织细胞的细胞毒性作用视而不见。在这项研究中，商业聚维酮碘虽然被认为是一种优秀的抗菌剂，但在临床前试验中发现它对哺乳动物细胞生长和伤口愈合有负面影响。在伤口治疗初期，甚至使伤口严重恶化，伤口面积扩大。然而，我们新配制的基于橡胶纳米粒子的碘伏能够通过抑制碘对哺乳动物组织造成的细胞毒性损伤来区分人类细胞和细菌细胞，并强力杀死细菌细胞，从而与聚维酮碘相比，在伤口护理方面表现出优异的性能。我们利用负载碘的乳液复合物的氧化还原组合将反式聚异戊二烯橡胶固化成纳米胶囊。具体来说，我们制造的橡胶纳米胶囊被证明能够促进显着的细胞增殖和伤口恢复，从而成为替代聚维酮碘的生物相容性和有利于愈合的伤口消毒剂的有希望的候选者。
Povidone-iodine has been leading the market of clinical disinfectants worldwide since the last century but has turned a blind eye to its cytotoxic effect on the cells of the human tissue. In this study, a commercial povidone-iodine, though considered an excellent antibacterial agent, was found to have a negative influence on mammal cell growth and wound healing in preclinical trials. At the early stage of wound treatment, it even severely deteriorated the wound and enlarged the wound area. However, our newly formulated iodophors, based on rubber nanoparticles, were able to discriminate between human and bacterial cells by inhibiting the cytotoxicity damage caused by iodine to mammalian tissue and vigorously, killed the bacterial cells, thereby, presenting as superior performers of wound care, compared with povidone-iodine. Wetook advantage of a redox combination of an emulsion complex loaded with iodine to solidify a trans-polyisoprene rubber into nanocapsules. Specifically, our fabricated class of rubber nanocapsules proved to be capable of promoting remarkable cell proliferation and wound recovery, thereby, serving as a promising candidate for biocompatible and healing-favored wound disinfection agents in place of povidone-iodine.