Effects of several volatile anesthetics on the Ca(2+)-related functions of skinned skeletal muscle fibers from the guinea pig.
Effects of several volatile anesthetics on the Ca(2+)-related functions of skinned skeletal muscle fibers from the guinea pig.
复制标题
几种挥发性麻醉剂对豚鼠去皮骨骼肌纤维 Ca(2) 相关功能的影响。
DOI：
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发表时间：
1991
影响因子：
--
通讯作者：
Makoto Endo
中科院分区：
文献类型：
--
作者：
Kazuyuki Matsui;Yasuhiro Fujioka;Hirosato Kikuchi;Osafumi Yuge;K. Fujii,;Michio Morio;Makoto Endo
采用豚鼠骨骼肌皮肤纤维技术，研究了不同挥发性麻醉药对豚鼠骨骼肌钙离子相关功能的影响。所有被测试的挥发性麻醉药在临床浓度下均显著增强肌浆网(SR)钙离子释放(CICR)，而对收缩系统的钙敏感性和肌浆网对钙的摄取几乎没有影响。比较了几种临床浓度的挥发性麻醉药对CICR的促进作用。氟烷的药效最强，其次是甲氧基氟烷、异氟醚、安氟醚、七氟烷和二乙醚。如果CICR在触发MH中起重要作用，则挥发性麻醉药对CICR增强作用的顺序也与其触发MH的效力相对应。
The effects of various volatile anesthetics on intramuscular Ca(2+)-related functions were studied with the skinned fiber technique in guinea pig skeletal muscles. All the volatile anesthetics tested significantly enhanced Ca(2+)-induced Ca2+ release (CICR) from the sarcoplasmic reticulum (SR) at clinical concentrations with negligible effects both on Ca2+ sensitivity of the contractile system and on Ca2+ uptake by the SR. A comparison was made of the enhancing effect of several volatile anesthetics on CICR at clinical concentrations. Halothane was the most potent, followed by methoxyflurane, isoflurane, enflurane, sevoflurane and diethyl ether. If CICR plays an important role in triggering MH, this order of volatile anesthetics on their enhancing effect on CICR, also corresponds to their potency in triggering MH.
易患恶性高热的猪肌浆网膜特性异常：氟烷、咖啡因、丹曲林和其他两种药物的作用方式。
影响因子：
3.9
作者：
Ohnishi,ST;Waring,AJ;Fang,SR;Horiuchi,K;Flick,JL;Sadanaga,KK;Ohnishi,T
通讯作者：
Ohnishi,T
正常和恶性高热易感猪肌肉肌浆网 Ca2 释放的动力学研究。
DOI：
10.1016/0005-2736(84)90187-1
发表时间：
1984
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Kim,DH;Sreter,FA;Ohnishi,ST;Ryan,JF;Roberts,J;Allen,PD;Meszaros,LG;Antoniu,B;Ikemoto,N
通讯作者：
Ikemoto,N