Transgenic mice and cytokine actions in the brain: bridging the gap between structural and functional neuropathology
Transgenic mice and cytokine actions in the brain: bridging the gap between structural and functional neuropathology
复制标题
DOI：
10.1016/s0165-0173(97)00038-6
复制
发表时间：
1998-05-01
影响因子：
--
通讯作者：
Campbell, IL
中科院分区：
文献类型：
--
作者：
Campbell, IL
破译脑细胞因子在体内表达的神经生物学后果代表了一个重要的研究目标，这对我们理解许多重要的神经系统疾病的发病机制和治疗具有重要意义。在我们自己对这一目标的追求中，我们的研究已经利用了采用GFAP启动子的转基因策略来指导细胞因子IL-3、IL-6、IFN-α或TNF-α在小鼠星形胶质细胞中的慢性表达。每种细胞因子的转基因表达产生独特的神经病理学和功能改变谱，从而直接暗示这些介质在CNS疾病的发病机制。此外，如这里用GFAP-IL 6转基因小鼠举例说明的，这些模型是进行多水平分析以将分子和细胞改变与特定的电生理学、神经内分泌和行为结果联系起来的有价值的工具。综合研究，如这里所描述的GFAP-细胞因子转基因小鼠，提供了一个更彻底的了解细胞因子在中枢神经系统和桥梁结构和功能神经病理学之间的差距差距的行动。(C)1998 Elsevier Science B. V.保留所有权利。
Deciphering the neurobiological consequences of cerebral cytokine expression in vivo represents an important research objective which has implications for our understanding of the pathogenesis and treatment of many significant neurological disorders. In our own pursuit of this objective, studies by us have utilized a transgenic strategy employing the GFAP promoter to direct the chronic expression of the cytokines IL-3, IL-6, IFN-alpha or TNF-alpha to astrocytes in mice. Transgenic expression of each cytokine produces a unique spectrum of neuropathological and functional alterations, thereby directly implicating these mediators in the pathogenesis of CNS disease. Moreover, as exemplified here with the GFAP-IL6 transgenic mice, these models are valuable tools in which to perform multi-level analysis to link molecular and cellular alterations to specific electrophysiological, neuroendocrine and behavioral outcomes. Integrative studies such as described here in the GFAP-cytokine transgenic mice, are providing a more thorough understanding of the actions of cytokines in the CNS and bridge the gap between structural and functional neuropathology. (C) 1998 Elsevier Science B.V. All rights reserved.