Enantioselective hydrogenation of 2-methyl-2-pentenoic acid over cinchonidine-modified Pd/alumina
Enantioselective hydrogenation of 2-methyl-2-pentenoic acid over cinchonidine-modified Pd/alumina
复制标题
2-甲基-2-戊烯酸在辛可尼定修饰的 Pd/氧化铝上的对映选择性氢化
DOI：
--
复制
发表时间：
1996
期刊：
影响因子：
--
通讯作者：
A. Baiker
中科院分区：
文献类型：
--
作者：
K. Borszéky;T. Mallát;A. Baiker
用辛可尼定-Pd/Al_2 O_3催化剂体系氢化α，β-不饱和羧酸制备了手性链烷酸，其（S）对映体过量达52%。有利条件是：高表面氢浓度（~ 60巴氢压力，低催化剂浓度和非极性溶剂），接近环境温度和辛可尼定/反应物摩尔比至少为0.4mol%。它建议，高的氢溶解度和2-甲基-2-戊烯酸反应物的存在下，作为二聚体是有利的对映体分化。
A chiral alkanoic acid was prepared with up to 52% excess of the (S) enantiomer by hydrogenating anα,β-unsaturated carboxylic acid with a cinchonidine-Pd/Al2O3 catalyst system. Favourable conditions are: high surface hydrogen concentration (⩾ 60 bar hydrogen pressure, low catalyst concentration and apolar solvents), near ambient temperature and a cinchonidine/reactantmolar ratio of at least 0.4 mol%. It is proposed that high hydrogen solubility and the presence of 2-methyl-2-pentenoic acid reactant as dimers are advantageous for enantiodifferentiation.