STRUCTURAL CHANGES OF PANCREATIC-ISLETS IN GENETICALLY OBESE RATS
STRUCTURAL CHANGES OF PANCREATIC-ISLETS IN GENETICALLY OBESE RATS
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DOI：
10.1007/bf01239438
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发表时间：
1973-01-01
期刊：
影响因子：
8.2
通讯作者：
SUZUOKI, Z
中科院分区：
文献类型：
--
作者：
SHINO, A;MATSUO, T;SUZUOKI, Z
对5 - 52周龄遗传性肥胖大鼠（Zucker，“脂肪”）的胰岛进行光镜和电镜观察。在5周龄时，胰岛中度肥大。在此年龄之后，胰岛肥大变得更加突出，直到24周龄，伴随着B细胞的脱粒。在此期间，血浆胰岛素水平也继续升高，但葡萄糖水平正常。脱颗粒的B细胞含有高度发达的高尔基复合体，大量囊泡状颗粒内质网和少量分泌颗粒，但无糖原沉积。这些B细胞的红细胞增多和微管形成非常显著。胰岛肥大时，胰腺内常见混合细胞或中间细胞，如外分泌-内分泌细胞或导管-内分泌细胞。在52周龄时，血浆胰岛素和甘油三酯水平均下降。在胰腺中，在肥大的胰岛中观察到纤维组织增生和颗粒状B细胞。因此，在肥胖大鼠中，胰岛在肥胖和高脂血症的发展期间（5至24周龄）处于活跃状态。这些肥胖和高胰岛素血症的相关性在52周龄时消失。
Light and electron microscopic observations were performed on pancreatic islets from genetically obese rats, (Zucker, “fatty”), from 5 to 52 weeks of age. At 5 weeks of age, islets were moderately hypertrophied. After that age, hypertrophy of islets became more prominent, until 24 weeks of age, with accompanying degranulation of B cells. The plasma insulin level also continued to increase during this period, but the glucose level was normal. Degranulated B cells contained a highly developed Golgi complex, numerous vesiculated, granular, endoplasmic reticulum and a small number of secretory granules, but no glycogen deposits. Emiocytosis and microtubule formation were very remarkable with these B cells. Frequently, mixed or intermediate cells, such as exocrine-endocrine or ductural-endocrine cell, were observed in pancreas with hypertrophied islets. At 52 weeks of age, both the plasma insulin and triglyceride levels decreased. In the pancreas, there were observed proliferation of fibrous tissue and well granulated B cells in hypertrophied islets. Hence, in fatty rats, pancreatic islets were in an active state during the period of development of obesity and hyperlipaemia (from 5 to 24 weeks of age). These correlates of obesity and hyperinsulinism disappeared at 52 weeks of age.