Ostwald ripening of β-carotene nanoparticles
Ostwald ripening of β-carotene nanoparticles
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DOI：
10.1103/physrevlett.98.036102
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发表时间：
2007-01-19
影响因子：
8.6
通讯作者：
Prud'homme, Robert K.
中科院分区：
文献类型：
--
作者：
Liu, Ying;Kathan, Kendra;Prud'homme, Robert K.
Ostwald熟化，即界面能驱动的溶质溶解和再沉淀，成为纳米颗粒配方的一个越来越重要的问题。我们首次对纳米粒子分散体的Ostwald成熟进行了定量研究。应用扩散驱动颗粒生长的Lifshitz-Slyosv-Wagner(LSW)理论，研究了由我们的嵌段共聚物保护的闪光纳米沉淀法形成的尺寸为O(100 Nm)的β-胡萝卜素纳米颗粒。给出了LSW理论的数值实现，该理论解释了原始颗粒的粒度分布。数值模拟得到的颗粒尺寸与动态光散射测量的实验结果进行了比较。结果表明，在没有可调参数的情况下，结果是定量一致的。抗溶剂的加入会显著降低整体的溶解度，从而导致熟化速率的降低。
Ostwald ripening, the interfacial-energy-driven dissolution and reprecipitation of solutes, becomes an increasingly significant problem for nanoparticle formulations. We present the first quantitative study of Ostwald ripening for nanoparticle dispersions. The Lifshitz-Slyozov-Wagner (LSW) theory of particle growth driven by diffusion is applied to study beta-carotene nanoparticles with sizes of O(100 nm) formed by our block-copolymer protected Flash Nanoprecipitation process. A numerical implementation of the LSW theory that accounts for the original particle size distribution is presented. The predicted particle sizes from the numerical simulation are compared with the experimental results measured by dynamical light scattering. The results show quantitative agreement with no adjustable parameters. The addition of antisolvent results in the reduction of the ripening rate by dramatically decreasing bulk solubility.