Biological functions of interleukin-21 and its role in inflammation.
Biological functions of interleukin-21 and its role in inflammation.
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DOI：
10.1100/tsw.2007.275
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发表时间：
2007-10-22
影响因子：
--
通讯作者：
Girard D
中科院分区：
文献类型：
--
作者：
Pelletier M;Girard D
白细胞介素-21 (IL-21) 是最近发现的 CD132 依赖性细胞因子，主要由活化的 T 淋巴细胞，特别是炎症性 Th17 亚群产生，被认为是先天免疫和获得性免疫之间过渡的关键因素。在过去几年中，这种细胞因子已被证明可以调节 T、B 和 NK 细胞以及骨髓来源细胞的功能。此外，研究还证明 IL-21 是一种有效的抗肿瘤药物，使其成为开发治疗工具的有希望的候选者。 IL-21 还与不同的自身免疫性疾病和炎症性疾病有关，例如类风湿性关节炎和炎症性肠病。本综述将总结IL-21的生物学功能及其在炎症中的潜在作用。
Interleukin-21 (IL-21), the most recently discovered CD132-dependent cytokine, is mainly produced by activated T lymphocytes, particularly the inflammatory Th17 subset, and is believed to be a key factor in the transition between innate and acquired immunity. In the last few years, this cytokine has been shown to modulate the functions of T, B, and NK cells, as well as cells of myeloid origin. In addition, it was demonstrated that IL-21 is a potent antitumor agent, making it a promising candidate for the development of therapeutic tools. IL-21 has also been associated with different autoimmune and inflammatory diseases, such as rheumatoid arthritis and inflammatory bowel disease. This review will summarize the biological functions of IL-21 and its potential role in inflammation.
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