Adults with patellofemoral pain do not exhibit manifestations of peripheral and central sensitization when compared to healthy pain-free age and sex matched controls – An assessor blinded cross-sectional study
Adults with patellofemoral pain do not exhibit manifestations of peripheral and central sensitization when compared to healthy pain-free age and sex matched controls – An assessor blinded cross-sectional study
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与年龄和性别匹配的健康无痛对照相比，患有髌股疼痛的成年人没有表现出外周和中枢敏化的表现——一项评估者盲法横断面研究
作者：
M. Rathleff;C. R. Rathleff;Aoife Stephenson;R. Mellor;M. Matthews;K. Crossley;B. Vicenzino
膝股关节痛(PFP)在成人和青少年中非常普遍。在PFP患者中观察到了膝关节和胫骨前肌周围的局限性机械性痛敏，但对中枢敏感化的潜在表现知之甚少。这项研究的目的是研究条件痛调制(CPM)和广泛分布的痛觉过敏在患有PFP的成年人中的作用。这项评估盲法横断面研究设计比较了33名确诊为PFP的成年人(23名女性)和32名年龄和性别匹配的无痛对照组的CPM和机械压力痛阈值(PPT)。进行PPT测量的研究人员被蒙在鼓里，不知道哪些参与者有PFP。使用Somedic手持式压力测痛仪可靠地测量了三个部位的PPT：1)膝盖骨中心，2)胫前肌和3)外上髁上的远处部位。为评估CPM，在冷水浴(条件性刺激)中诱导对侧手的实验性疼痛，并在条件性刺激之前和之后立即进行PPTS(测试刺激)的评估。平均而言，CPM范式导致三个部位的PPTs显著增加(6.3-13.5%，P<；0.05)，但青壮年PFP患者的CPM与对照组相比没有差异，(F(1,189)=0.39，P=0.89)。两组机械性PPTs差异无统计学意义(F(1,189)=0.03，P=0.86)。与我们的先验假设相反，我们发现患有PFP的年轻人与年龄和性别匹配的无痛对照组之间的CPM或PPT没有差异。
Patellofemoral Pain (PFP) is highly prevalent among adults and adolescents. Localized mechanical hyperalgesia around the knee and tibialis anterior have been observed in people with PFP, but limited knowledge of potential manifestations of central sensitisation exists. The aims of this study were to study conditioned pain modulation (CPM) and wide-spread hyperalgesia in adults with PFP. This assessor-blinded cross-sectional study design compared CPM and mechanical pressure pain thresholds (PPT) between 33 adults (23 females) diagnosed with PFP and 32 age and sex matched pain-free controls. The investigator taking the PPT measurements was blinded to which participants had PFP. PPTs were reliably measured using a Somedic hand-held pressure algometer at three sites: 1) The centre of the patella, 2) the tibialis anterior muscle and 3) a remote site on the lateral epicondyle. For the assessment of CPM, experimental pain was induced to the contralateral hand by immersion into a cold water bath (conditioning stimulus), and assessment of PPTs (the test stimulus) was performed before and immediately after the conditioning stimulation. On average, the CPM paradigm induced a significant increase in PPTs across the three sites (6.3–13.5%, P<0.05), however there was no difference in CPM between young adults with PFP compared to the control group, (F(1,189) = 0.39, P = 0.89). There was no difference in mechanical PPTs between the two groups (F(1,189) = 0.03, P = 0.86). Contrary to our a-priori hypothesis, we found no difference in CPM or PPT between young adults with PFP and age and sex matched pain-free controls.
膝盖疼痛图：识别膝盖疼痛位置和模式的方法的可靠性。
影响因子：
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作者：
Thompson,LauraR;Boudreau,Robert;Hannon,MichaelJ;Newman,AnneB;Chu,ConstanceR;Jansen,Mary;Nevitt,MichaelC;Kwoh,CKent;OsteoarthritisInitiativeInvestigators
通讯作者：
OsteoarthritisInitiativeInvestigators