Expression of chemokine receptor CXCR 5 in gastric cancer and its clinical significance
Expression of chemokine receptor CXCR 5 in gastric cancer and its clinical significance
复制标题
DOI：
--
复制
发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Qingcan Sun;Lujun Chen;Bin Xu;Qi Wang;Xiao Zheng;Peng Du;Dachuan Zhang;Changping Wu;Jingting Jiang
中科院分区：
文献类型：
--
作者：
Qingcan Sun;Lujun Chen;Bin Xu;Qi Wang;Xiao Zheng;Peng Du;Dachuan Zhang;Changping Wu;Jingting Jiang
The increased expression of chemokine receptor CXCR5 in cancers has been demonstrated. In order to characterize the expression pattern of CXCR5 in cell lines and tissues of gastric cancer and to assess clinical implications, the expression of CXCR5 mRNA in gastric cancer tissues and adjacent tissues was evaluated by realtime RT-PCR. Meanwhile, the expression of CXCR5 in cell lines of human gastric cancer was also analyzed by flow cytometry. Tissue microarray and immunohistochemistry were used to detect the protein expression of CXCR5 in human gastric cancer tissues and adjacent normal tissues. Flow cytometry results revealed the positive expression of CXCR5 in human gastric cancer cell lines such as BGC-823, SGC-7901 and HGC-27 cells. The immunohistochemistry results showed higher expression of CXCR5 in 52.87% of gastric cancer tissues. The expression of CXCR5 in patients with tumor size less than 2.8 cm subgroup was significantly lower than that in patients with tumor size larger than 2.8 cm subgroup (P = 0.0456). There was no significant correlation between the expression of CXCR5 and other clinical parameters in gastric cancer. Moreover, the survival analysis showed that the overall survival rate of the patients with higher CXCR5 expression was lower than that of the patients with lower CXCR5 expression (P = 0.0579, HR = 1.810, 95% CI: 0.9803-3.341). The results suggest that CXCR5 is involved in the oncogenesis and progression of gastric cancer.
