EEG Power During Waking and NREM Sleep in Primary Insomnia
EEG Power During Waking and NREM Sleep in Primary Insomnia
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DOI：
10.5664/jcsm.3076
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发表时间：
2013-01-01
影响因子：
4.3
通讯作者：
Buysse, Daniel J.
中科院分区：
文献类型：
--
作者：
Meme, You;Pietrone, Regina;Buysse, Daniel J.
目的：失眠的病理生理模型援引了24小时高觉醒的概念，这可能导致清醒和睡眠期间的症状和生理结果。我们假设这种觉醒可以在原发性失眠症（PI）患者的醒时脑电图（EEG）中看到，并且醒时脑电图功率与非快速眼动（NREM）脑电图相关。方法：PI 50例，良好睡眠者32例。在正常睡眠时间采集5分钟闭眼清醒脑电图，在习惯睡眠时间采集多导睡眠图（PSG）。使用自动算法和可视化编辑去除清醒和睡眠脑电图中的伪影，然后进行功率谱分析以估计0.5-32 Hz的功率。结果：我们发现PI和GSC在清醒和非快速眼动期脑电图频谱功率上无显著差异。在PI组的所有频带和GSC组的大多数频带中观察到清醒和非快速眼动睡眠功率之间的显著相关性。结论：两组之间在清醒或非快速眼动期的脑电图功率没有显著差异，这表明我们的样本不具有高度皮层觉醒的特征。清醒和非快速眼动脑电图功率之间的一致性相关性表明，在非快速眼动脑电图β活动升高的样本中，清醒脑电图功率可能表现出类似的模式。
Objective: Pathophysiological models of insomnia invoke the concept of 24-hour hyperarousal, which could lead to symptoms and physiological findings during waking and sleep. We hypothesized that this arousal could be seen in the waking electroencephalogram (EEG) of individuals with primary insomnia (PI), and that waking EEG power would correlate with non-REM (NREM) EEG.Methods: Subjects included 50 PI and 32 good sleeper controls (GSC). Five minutes of eyes closed waking EEG were collected at subjects' usual bedtimes, followed by polysomnography (PSG) at habitual sleep times. An automated algorithm and visual editing were used to remove artifacts from waking and sleep EEGs, followed by power spectral analysis to estimate power from 0.5-32 Hz.Results: We did not find significant differences in waking or NREM EEG spectral power of PI and GSC. Significant correlations between waking and NREM sleep power were observed across all frequency bands in the PI group and in most frequency bands in the GSC group.Conclusions: The absence of significant differences between groups in waking or NREM EEG power suggests that our sample was not characterized by a high degree of cortical arousal. The consistent correlations between waking and NREM EEG power suggest that, in samples with elevated NREM EEG beta activity, waking EEG power may show a similar pattern.