Epidemiology of acute encephalopathy in Japan, with emphasis on the association of viruses and syndromes
Epidemiology of acute encephalopathy in Japan, with emphasis on the association of viruses and syndromes
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DOI：
10.1016/j.braindev.2011.07.012
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发表时间：
2012-05-01
影响因子：
1.7
通讯作者：
Mizuguchi, Masashi
中科院分区：
文献类型：
--
作者：
Hoshino, Ai;Saitoh, Makiko;Mizuguchi, Masashi
日本政府支持的一个研究委员会使用问卷调查表对日本急性脑病的流行病学进行了全国性调查。据报道，在过去3年（2007-2010年）中，共有983例急性脑病。在既往感染的病原体中，流感病毒最常见，其次是人类疱疹病毒-6（HHV-6）和轮状病毒。在急性脑病综合征中，急性脑病伴双相癫痫发作和迟发性弥散减低（AESD）最常见，其次是临床轻度脑炎/脑病伴可逆性脾损伤（MERS）、急性坏死性脑病（ANE）和出血性休克和脑病综合征（HSES）。流感病毒与ANE和MERS密切相关，HHV-6与AESD密切相关，轮状病毒与MERS密切相关。ANE和HSES的死亡率较高，但AESD、MERS和HHV-6相关脑病的死亡率较低。神经系统后遗症在AESD和ANE中常见，但在MERS中不存在。(C)2011年日本儿童神经病学学会。Elsevier B. V.出版，保留所有权利。
A research committee supported by the Japanese government conducted a nationwide survey on the epidemiology of acute encephalopathy in Japan using a questionnaire. A total of 983 cases reportedly had acute encephalopathy during the past 3 years, 2007-2010. Among the pathogens of the preceding infection, influenza virus was the most common, followed by human herpesvirus-6 (HHV-6) and rotavirus. Among syndromes of acute encephalopathy, acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) was the most frequent, followed by clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS), acute necrotizing encephalopathy (ANE) and hemorrhagic shock and encephalopathy syndrome (HSES). Influenza virus was strongly associated with ANE and MERS, HHV-6 with AESD, and rotavirus with MERS. Mortality was high in ANE and HSES, but was low in AESD, MERS and HHV-6-associated encephalopathy. Neurologic sequelae were common in AESD and ANE, but were absent in MERS. (C) 2011 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.