Self-assembly of conjugated polymers and ds-oligonucleotides directed fractal-like aggregates
Self-assembly of conjugated polymers and ds-oligonucleotides directed fractal-like aggregates
复制标题
共轭聚合物和双链寡核苷酸定向分形聚集体的自组装
DOI：
10.1021/bm070082k
复制
发表时间：
2007-05-01
影响因子：
6.2
通讯作者：
Zhu, Daoben
中科院分区：
文献类型：
--
作者：
Gan, Haiyang;Li, Yuliang;Zhu, Daoben
共轭聚合物和双链寡核苷酸之间的高度有序纳米结构首先通过简单地控制自组装过程来制造，这展示了制造分形结构的新概念。聚合物/DNA 分形状聚集体的形成是一个扩散限制聚集 (DLA) 过程。分形维数与聚合物/DNA浓度无关，但仅与聚合物/DNA电荷比有关。更有趣的是，聚合物和 DNA 之间不同的荧光共振能量转移 (FRET) 行为可用于区分 dsDNA 和 ssDNA。
Highly ordered nanostructures between conjugated polymers and ds-oligonucleotides have been first fabricated by simply controlling the self-assembly processes, which shows a novel concept for fabricating fractal-like structures. The formation of polymer/DNA fractal-like aggregates is a diffusion-limited aggregation (DLA) process. The fractal dimension is independent of the polymer/DNA concentration but only related to the polymer/DNA charge ratio. More interestingly, the different fluorescent resonance energy transfer (FRET) behavior between the polymer and the DNA can be used to distinguish dsDNA from ssDNA.