Attenuation of the development of murine solid leukemia tumor by physical exercise
Attenuation of the development of murine solid leukemia tumor by physical exercise
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DOI：
10.1089/152308602753625979
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发表时间：
2002-02-01
影响因子：
6.6
通讯作者：
Goto, S
中科院分区：
文献类型：
--
作者：
Radak, Z;Gaal, D;Goto, S
体育锻炼在多种癌症的演变过程中的积极参与已有充分记录。然而，其在实体白血病肿瘤发展中的作用基本上是未知的。将实体白血病肿瘤细胞移植到 21 只杂交 BDF1 对照小鼠、经过运动训练但在白血病期间不运动的小鼠以及经过运动训练但在白血病期间进行运动的小鼠体内。移植后18天，持续运动组的肿瘤大小与对照组和运动终止动物的肿瘤大小相似50%。三组肿瘤中抗氧化酶的活性以及脂质过氧化和8-羟基-2'-脱氧鸟苷的水平没有差异。持续运动动物的肿瘤中羰基化蛋白质的水平较低。细胞调节蛋白p53和血管内皮生长因子的突变形式在每组肿瘤细胞中以相似的量存在。另一方面，原癌基因 Ras 和 I-kappaB 蛋白在持续运动的大鼠肿瘤中以较高浓度存在。目前的数据表明，白血病期间的运动可以减轻小鼠肿瘤的发展。调节蛋白的选择性改变可能在白血病期间运动的有益作用中发挥作用。
The active involvement of physical exercise in the evolution of a variety of cancers is well documented. However, its role in solid leukemia tumor development is essentially unknown. Solid leukemia tumor cells were transplanted into 21 hybrid BDF1 control mice, exercise-trained mice that did not exercise during leukemia and exercise-trained mice that exercised during leukemia. The tumor size of the continuously exercising group was similar to50% of that of control and exercise-terminated animals 18 days after the transplantation. The activity of antioxidant enzymes and the levels of lipid peroxidation and 8-hydroxy-2'-deoxyguanosine were not different in the tumors of the three groups. The level of carbonylated proteins was smaller in tumors of continuously exercising animals. The mutant form of cell regulatory protein p53 and vascular endothelial growth factor were present in similar amounts in the tumor cells of each group. On the other hand, the protooncogene Ras and I-kappaB proteins were present in higher concentrations in tumors of continuously exercising rats. The present data suggest that exercise during leukemia attenuates the development of tumors in mice. The selective alteration of regulatory proteins might play a role in the beneficial effects of exercise during leukemia.