Protection of normal tissue against late radiation injury by WR-2721.
Protection of normal tissue against late radiation injury by WR-2721.
复制标题
WR-2721 保护正常组织免受晚期辐射损伤。
作者：
J. Utley;C. A. Quinn;F. White;N. Seaver;C. Bloor
研究了WR-2721在大鼠皮肤、肌肉和血管组织中对晚期辐射损伤的保护作用。接受WR-2721和未接受WR-2721治疗的动物接受左后肢照射；每隔72小时至6个月处死代表性组。所有药物治疗动物与未药物治疗动物的比较均显示出显著的保护作用（P =小于或等于0.05）。未给药大鼠损伤时间模式为两期，72 h和1周出现明显损伤，1 ~ 3个月恢复正常，6个月出现明显晚期损伤（P =小于等于0.001）。同样，wr -2721治疗的大鼠没有出现这种损伤模式。因此，WR-2721对血管、皮肤和肌肉的急性和慢性辐射损伤的保护能力表明，当该药物用于临床放射治疗时，可以预期增加的治疗效果。
The ability of WR-2721 to protect against late radiation damage has been studied in skin, muscle, and vascular tissues of rats. Animals treated with and without WR-2721 received irradiation to the left hind limb; representative groups were killed at intervals ranging from 72 h to 6 months. Comparison of all drug-treated and non-drug-treated animals showed significant protection (P = less than or equal to 0.05). The time pattern of injury in non-drug-treated rats was biphasic, with significant damage occurring at 72 h and 1 week, returning to normal between 1 and 3 months, but showing significant late damage at 6 months (P = less than or equal to 0.001). Again, this injury pattern did not appear in WR-2721-treated rats. Thus the ability of WR-2721 to protect against acute and chronic radiation injury in vessels, skin, and muscle indicates that an increased therapeutic gain can be expected when this drug is used in clinical radiation therapy.