Dermal Hypersensitivity to Toxoplasma Antigens (Toxoplasmins)
Dermal Hypersensitivity to Toxoplasma Antigens (Toxoplasmins)
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皮肤对弓形虫抗原（弓形虫）过敏
DOI：
10.3181/00379727-68-16579
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发表时间：
1948
期刊：
影响因子：
--
通讯作者：
J. K. Frenkel
中科院分区：
文献类型：
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作者：
J. K. Frenkel
本文介绍了弓形虫皮试抗原弓形虫素的制备方法。弓形虫素在某些病人中引起迟发型（结核菌素）超敏反应。弓形虫超敏反应与弓形虫中和抗体的存在高度相关。后者的滴度可能非常低，并且在注射皮试剂量后出现既往升高之前可能无法明确证实。由于操作简便，结果快速明确，在分离病原体不可行的情况下，弓形虫菌素皮肤试验是诊断既往或潜伏弓形虫病最有用的单一辅助手段。皮肤超敏反应试验有助于新生儿脑积水的鉴别诊断。
Summary The preparation of toxoplasmin, a skin testing antigen made of toxoplasma has been described. Toxoplasmin evokes reactions of a delayed (tuberculin) type of hypersensitivity in certain patients. There is a high correlation between toxoplasmin hypersensitivity and the presence of toxoplasma neutralizing antibodies. The latter may be of very low titre and may not be unequivocally demonstrable until an anamnestic rise has occurred following the injection of the skin test dose. The ease of performance and the rapidity with which clear-cut results are obtained, make the toxoplasmin skin test the most useful single aid in the diagnosis of past or latent toxoplasmosis, wherever isolation of the caustive organism is not feasible. A test based on dermal hypersensitivity has been described facilitating the differential diagnosis of neonatal hydrocephalus.