Long-term progression of retinopathy after initiation of insulin therapy in Type 2 diabetes: an observational study
Long-term progression of retinopathy after initiation of insulin therapy in Type 2 diabetes: an observational study
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DOI：
10.1007/s00125-004-1473-9
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发表时间：
2004-08-01
期刊：
影响因子：
8.2
通讯作者：
Taylor, R
中科院分区：
文献类型：
--
作者：
Arun, CS;Pandit, R;Taylor, R
目的/假设。在以前的研究中已经提出2型糖尿病患者开始胰岛素治疗后视网膜病变普遍恶化。我们研究了294例此类患者长达5年，以评估视网膜变化并确定影响视网膜病变进展的因素。使用EURODIAB系统对每年的视网膜照片进行分级。在胰岛素治疗前，26.2%（77/294）的患者有轻度非增殖性糖尿病视网膜病变（NPDR），3.7%（n=11）有中度NPDR，1%（n=3）有重度NPDR。在胰岛素治疗的前3年内，36例受试者（12.6%）发生了显著进展。其中5/193例（2.6%）基线时无任何视网膜病变，22/77例（28.5%）有轻度NPDR，6/11例（54.5%）有中度NPDR（卡方2 =56.1，p
Aims/hypothesis. Universal worsening of retinopathy after starting insulin therapy in Type 2 diabetes has been suggested in previous work.Methods. We studied 294 such patients for up to 5 years to evaluate retinal changes and define the factors affecting progression of retinopathy. Yearly retinal photographs were graded using the EURODIAB system.Results. Prior to insulin therapy, 26.2% (77/294) of the patients had minimal non-proliferative diabetic retinopathy (NPDR), 3.7% (n=11) had moderate NPDR and 1% (n=3) had severe NPDR. Over the first 3 years of insulin therapy, significant progression occurred in 36 subjects (12.6%). This comprised 5/193 (2.6%) without any retinopathy at baseline, 22/77 (28.5%) with minimal NPDR and 6/11 with moderate NPDR (54.5%) (chi(2)=56.1, p