Surgical complications associated with sentinel lymph node dissection (SLND) plus axillary lymph node dissection compared with SLND alone in the American College of Surgeons oncology Group trial Z0011
Surgical complications associated with sentinel lymph node dissection (SLND) plus axillary lymph node dissection compared with SLND alone in the American College of Surgeons oncology Group trial Z0011
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DOI：
10.1200/jco.2006.07.4062
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发表时间：
2007-08-20
影响因子：
45.3
通讯作者：
Giuliano, Armando E.
中科院分区：
文献类型：
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作者：
Lucci, Anthony;McCall, Linda Mackie;Giuliano, Armando E.
目的美国外科医师学会肿瘤组试验Z 0011是一项前瞻性、随机、多中心试验，比较前哨淋巴结（SLN）阳性患者行和未行腋窝淋巴结清扫术（ALND）的总生存率。目前的研究比较与SLN夹层（SLND）加ALND，与SLND单独的并发症。患者和MethodsFrom 1999年5月至2004年12月，891例患者被随机分配到SLND + ALND（n = 445）或SLND单独（n = 446）。结果SLND + ALND组术后不良反应发生率为70%（278/399），单纯SLND组为25%（103/411）（P
PurposeThe American College of Surgeons Oncology Group trial Z0011 was a prospective, randomized, multicenter trial comparing overall survival between patients with positive sentinel lymph nodes ( SLNs) who did and did not undergo axillary lymph node dissection ( ALND). The current study compares complications associated with SLN dissection ( SLND) plus ALND, versus SLND alone.Patients and MethodsFrom May 1999 to December 2004, 891 patients were randomly assigned to SLND + ALND ( n = 445) or SLND alone ( n = 446). Information on wound infection, axillary seroma, paresthesia, brachial plexus injury ( BPI), and lymphedema was available for 821 patients.ResultsAdverse surgical effects were reported in 70% ( 278 of 399) of patients after SLND + ALND and 25% ( 103 of 411) after SLND alone ( P