Increased cytokine release from peripheral blood cells after acute stroke
Increased cytokine release from peripheral blood cells after acute stroke
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DOI：
10.1097/00004647-199909000-00008
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发表时间：
1999-09-01
影响因子：
6.3
通讯作者：
De Simoni, MG
中科院分区：
文献类型：
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作者：
Ferrarese, C;Mascarucci, P;De Simoni, MG
细胞因子白细胞介素 (IL)-6 和肿瘤坏死因子 (TNF)-α 在中风中发挥致病或保护作用。它们在实验性缺血后的大脑和中风患者的脑脊液中增加。然而，它们在外围的存在仍然存在争议。为了确定中风患者血液中细胞因子的来源和过程，我们测定了 40 名患者在中风后第 1 至 2、4、10、30 和 90 天从血细胞中释放的 IL-6 和 TNF-α 以及血清水平。二十名年龄匹配的健康志愿者被用作对照。与对照组相比，中风患者受刺激的血细胞释放的 IL-6 和 TNF-α 增加。在第 4 天观察到 IL-6 的峰值反应 (+224%)，而从中风后第 1 天到第 2 天直至第 90 天，TNF-α 释放大幅增加（与对照相比约三倍）。与出血性中风相比，第 1 天和第 1 天，缺血性中风中 IL-6 释放的增加显着更高。循环中的 IL-6 在每个时间点都增加。中枢神经系统的缺血过程会诱导外周血细胞中 IL-6 和 TNF-α 产生的长期激活，而外周血细胞是中风后血清细胞因子的主要来源。
Cytokines interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha can play pathogenetic or protective roles in stroke. They are increased in the brain after experimental ischemia and in the CSF of patients with stroke. However, their presence in the periphery is still controversial. To determine the source and lime-course of cytokines in blood of stroke patients, IL-6 and TNF-alpha release from blood cells and serum levels were determined in 40 patients on days 1 through 2, 4, 10, 30, and 90 after stroke. Twenty healthy age-matched volunteers were used as controls. IL-6 and TNF-alpha release from stimulated blood cells was increased in stroke patients, compared to controls. A peak response (+224%) was observed at day 4 for IL-6, while TNF-alpha release was largely and significantly increased (about three-fold compared to controls) from day 1 to 2 until day 90 after stroke. The increase in IL-6 release was significantly higher in ischemic, compared to hemorragic strokes, at days 1 and 1. Circulating IL-6 was increased at each time point. The ischemic processes in the CNS induces a long-lasting activation of IL-6 and TNF-alpha production in peripheral blood cells, which are a major source of serum cytokines after stroke.