Supramolecular Nanodiscs Self-Assembled from Non-Ionic Heptamethine Cyanine for Imaging-Guided Cancer Photothermal Therapy
Supramolecular Nanodiscs Self-Assembled from Non-Ionic Heptamethine Cyanine for Imaging-Guided Cancer Photothermal Therapy
复制标题
由非离子七次甲基花青自组装的超分子纳米圆盘用于成像——引导癌症光热治疗
DOI：
10.1002/adma.201906711
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发表时间：
2019-11-27
影响因子：
29.4
通讯作者：
Li, Zhibo
中科院分区：
文献类型：
--
作者：
Mu, Xueluer;Lu, Yingxi;Li, Zhibo
超分子纳米药物，利用超分子设计来提高制药实践的准确性和有效性，并优化药代动力学特征，已经聚集了对抗癌症和其他不治之症的势头，传统的小分子和大分子药物对这些疾病的疗效较差。然而，缺乏临床批准的基于超分子组装的药物强调了该领域面临的挑战。由非离子型七甲基菁（Cy7）染料形成二维纳米圆盘超分子结构，产生荧光自猝灭，但具有独特的光热和光声特性。这些基于Cy7的超分子纳米片具有被动肿瘤靶向特性，不仅可以通过近红外荧光成像和光声断层扫描显示肿瘤，还可以在照射下诱导光热肿瘤消融。由于有机小分子的性质，它们在小鼠体内引起不可检测的急性毒性，并且可以被肝脏消除，不需要肝外代谢。这些发现表明，自组装的花青素圆盘代表了一种新的药物递送模式，作为单组分超分子纳米药物，可以自我递送和自我配制，并为协同临床癌症成像和治疗提供了一个平台技术。
Supramolecular nanomedicines, which use supramolecular design to improve the precision and effectiveness of pharmaceutical practice and optimize pharmacokinetic profiles, have gathered momentum to battle cancer and other incurable diseases, for which traditional small‐molecular and macromolecular drugs are less effective. However, the lack of clinical approval of supramolecular assembly‐based medicine underscores the challenges facing this field. A 2D nanodisc‐based supramolecular structure is formed by a non‐ionic heptamethine cyanine (Cy7) dye, which generates fluorescence self‐quenching but unique photothermal and photoacoustic properties. These Cy7‐based supramolecular nanodiscs exhibit passive tumor‐targeting properties to not only visualize the tumor by near‐infrared fluorescence imaging and photoacoustic tomography but also induce photothermal tumor ablation under irradiation. Due to the nature of organic small molecule, they induce undetectable acute toxicity in mice and can be eliminated by the liver without extrahepatic metabolism. These findings suggest that the self‐assembling cyanine discs represent a new paradigm in drug delivery as single‐component supramolecular nanomedicines that are self‐delivering and self‐formulating, and provide a platform technology for synergistic clinical cancer imaging and therapy.