Risk and Timing of Tuberculosis Among Close Contacts of Persons with Infectious Tuberculosis.
Risk and Timing of Tuberculosis Among Close Contacts of Persons with Infectious Tuberculosis.
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DOI：
10.1093/infdis/jiy265
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发表时间：
2018-08-14
期刊：
影响因子：
--
通讯作者：
Tuberculosis Epidemiologic Studies Consortium Task Order 2 Team
中科院分区：
文献类型：
--
作者：
Reichler MR;Khan A;Sterling TR;Zhao H;Moran J;McAuley J;Bessler P;Mangura B;Tuberculosis Epidemiologic Studies Consortium Task Order 2 Team
最近接触传染性结核病患者的密切接触者患结核病的风险和时间尚不明确。我们前瞻性招募了美国和加拿大9个卫生部门的≥15岁的培养确诊肺结核患者及其密切接触者。对密切接触者进行筛查，并与结核病登记处进行交叉匹配，以确定患结核病的人。在718名结核病患者中，4490名接触者中有158名（4%）被诊断为结核病。在接触者中的结核病例中，在索引患者诊断后1、3、6和12个月分别诊断出81例（51%）、119例（75%）、128例（81%）和145例（92%）。在指标患者诊断后的连续5年中，接触者中的结核病发病率分别为2644、115、46、69和25例/10万人。在接触者中的结核病例中，121例（77%）通过接触者调查确定，37例（23%）通过结核病登记交叉配血确定。与传染性结核病患者密切接触者的结核病发病率较高，大多数疾病在指示患者确诊前或确诊后3个月内确诊。需要及时进行接触者调查以检测结核病，并最大限度地增加识别和治疗潜伏感染的机会，以预防疾病。
The risk and timing of tuberculosis among recently exposed close contacts of patients with infectious tuberculosis are not well established. We prospectively enrolled patients ≥15 years of age with culture-confirmed pulmonary tuberculosis and their close contacts at 9 health departments in the United States and Canada. Close contacts were screened and cross-matched with tuberculosis registries to identify those who developed tuberculosis. Tuberculosis was diagnosed in 158 of 4490 contacts (4%) of 718 index patients with tuberculosis. Of tuberculosis cases among contacts, cumulative totals of 81 (51%), 119 (75%), 128 (81%), and 145 (92%) were diagnosed by 1, 3, 6, and 12 months, respectively, after the index patients’ diagnosis. Tuberculosis rates among contacts were 2644, 115, 46, 69, and 25 cases per 100 000 persons, respectively, in the 5 consecutive years after the index patients’ diagnosis. Of the tuberculosis cases among contacts, 121 (77%) were identified by contact investigation and 37 (23%) by tuberculosis registry cross-match. Close contacts to infectious patients with tuberculosis had high rates of tuberculosis, with most disease diagnosed before or within 3 months after the index patient’ diagnosis. Contact investigations need to be prompt to detect tuberculosis and maximize the opportunity to identify and treat latent infection, to prevent disease.
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DOI：
10.1183/09031936.00070812
发表时间：
2013-01
期刊：
The European respiratory journal
影响因子：
--
作者：
Fox GJ;Barry SE;Britton WJ;Marks GB
通讯作者：
Marks GB
影响因子：
12.7
作者：
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通讯作者：
Moore, M
影响因子：
158.5
作者：
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通讯作者：
Rubin, Eric J.
影响因子：
120.7
作者：
Reichler, MR;Reves, R;Onorato, IM
通讯作者：
Onorato, IM
影响因子：
120.7
作者：
Zuber, PLF;McKenna, MT;Castro, KG
通讯作者：
Castro, KG