Flow injection method for determination of uranium in urine and serum by inductively coupled plasma mass spectrometry
Flow injection method for determination of uranium in urine and serum by inductively coupled plasma mass spectrometry
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DOI：
10.1016/s0003-2670(96)00278-4
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发表时间：
1996-11
影响因子：
6.2
通讯作者：
A. Lorber;Z. Karpas;L. Halicz
中科院分区：
文献类型：
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作者：
A. Lorber;Z. Karpas;L. Halicz
非职业接触铀化合物人群的尿铀浓度范围为1-40 ng L−1，中位数约为10 ng L−1。这对常规分析具有挑战性，因为在如此低的水平下，很难在样品制备过程中防止污染。该方法基于流动注射进样和电感耦合等离子体质谱检测，除了用几滴硝酸酸化尿样外，几乎不需要样品前处理。分析完全自动化，速度快，每个样品分析时间为60 S。检测下限为1.5 ng L−1。在载流中加入1g L−1表面活性剂(Triton-X100)可降低记忆效应和基质效应。通过对标准参考物质的测量，标准稀释实验，以及在较高浓度下与基于激光诱导荧光的独立方法所获得的结果的比较，证明了结果的有效性。
The uranium concentration in urine of a population that is not occupationally exposed to uranium compounds is in the range 1–40 ng l−1with a median around 10 ng l−1. This is analytically challenging for routine analysis because at such low levels it is difficult to prevent contamination during sample preparation. The method presented here is based on sample introduction via a flow injection analysis system and inductively coupled plasma mass spectrometric detection, and requires virtually no sample preparation, except for acidification of the urine sample with a few drops of HNO3The analysis is fully automated and fast with an analysis time of 60 s per sample. The lower limit of detection is 1.5ng l−1. Memory and matrix effects may be decreased by adding 1 g l−1of a surfactant (Triton-X 100) to the carrier stream. The validity of the results is demonstrated through measurement of standard reference materials, standard dilution experiments and, at higher concentrations, by comparison with results obtained by an independent method based on laser induced fluorescence.