Genetic polymorphisms of HSP70 in age-related cataract
Genetic polymorphisms of HSP70 in age-related cataract
复制标题
DOI：
10.1007/s12192-013-0420-4
复制
发表时间：
2013-11-01
影响因子：
3.8
通讯作者：
Liu, Ping
中科院分区：
文献类型：
--
作者：
Zhang, Yi;Gong, JianYing;Liu, Ping
目前已发现多个HSP 70基因存在多态性，这可能影响HSP 70的修复效率。我们研究了中国人群中热休克蛋白修复途径中HSPA 1A、HSPA 1B和HSPA 1 L基因多态性与白内障风险的关系。该研究包括415名白内障患者和386名对照。采用聚合酶链反应-限制性片段长度多态性方法进行基因分型。HSPA 1B 1267 A/A基因型可能对白内障具有保护作用（p = 0.014，比值比（OR）= 0.664，95%置信区间（CI）= 0.480-0.919），G等位基因（p = 0.057，OR = 1.216，95%CI = 0.999-1.479）似乎在白内障的发展中没有有害作用。单倍型与GAT的频率显着不同，与对照组（p = 0.005）。在HSPA 1A G190 C和HSPA 1 L T2437 C多态性中，与对照组相比，患者中变体纯合子的频率没有显著差异。结论HSPA 1B基因A1267 G多态性A/A基因型可能对老年性白内障具有保护作用。
Polymorphisms have been identified in several HSP70 genes, which may affect HSP70 repair efficiency. We investigated the association of the polymorphisms in HSPA1A, HSPA1B, and HSPA1L genes in the HSPs repair pathway with the risk of cataract in a Chinese population. The study included 415 cataract patients and 386 controls. Genotyping was done by the polymerase chain reaction-restriction fragment length polymorphism method. HSPA1B 1267 A/A genotype seems to have a protective role against cataract (p = 0.014, odds ratio (OR) = 0.664, 95 % confidence intervals (CI) = 0.480-0.919), and the G allele (p = 0.057, OR = 1.216, 95 % CI = 0.999-1.479) does not seem to have a deleterious role in the development of cataract. Haplotypes with frequencies of GAT were significantly different than those of controls (p = 0.005). In HSPA1A G190C and HSPA1L T2437C polymorphisms, there were no significant differences in frequencies of the variant homozygous in patients compared to controls. We conclude that the A/A genotype of HSPA1B A1267G polymorphism seem to have a protective role against age-related cataract.