AureoWiki-The repository of the Staphylococcus aureus research and annotation community
AureoWiki-The repository of the Staphylococcus aureus research and annotation community
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DOI：
10.1016/j.ijmm.2017.11.011
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发表时间：
2018-08-01
影响因子：
4.1
通讯作者：
Maeder, Ulrike
中科院分区：
文献类型：
--
作者：
Fuchs, Stephan;Mehlan, Henry;Maeder, Ulrike
鉴于关于人类主要病原体的数据和知识不断积累，迫切需要全面和最新的、易于获取的信息来源。AureoWiki数据库(http://aureowiki.med.uni-greifswald.de))提供了临床和实验相关金黄色葡萄球菌菌株的基因和蛋白质的详细信息，目前涵盖NCTC8325、COL、纽曼、USA300FPR3757和N315。通过实施泛基因组方法，AureoWiki促进了在不同金黄色葡萄球菌菌株研究中获得的知识的转移，从而支持功能注释和对这种有机体的更好理解。所有与给定基因或基因产物相关的数据都汇编在特定菌株的基因页面上。基因页面包含以序列为基础的信息，辅以例如蛋白质功能和定位、转录调控和基因表达的数据。所提供的信息通过链接连接到其他数据库和出版的文献。重要的是，通过泛基因组基因识别符和统一的基因名称连接的单个菌株的同源基因使用菌株特定的标签并排显示。各自的泛基因组基因页面包含32个金黄色葡萄球菌菌株的同源表、多个菌株基因组查看器、蛋白质序列比对以及其他比较信息。还可以通过各种下载选项访问在AureoWiki中收集的数据，以支持生物信息学应用程序。此外，基于两个大规模的基因表达数据集，AureoWiki提供了各种实验室和感染相关条件下依赖条件的mRNA水平和蛋白质谱的图形表示。
In light of continuously accumulating data and knowledge on major human pathogens, comprehensive and up-to-date sources of easily accessible information are urgently required. The AureoWiki database (http://aureowiki.med.uni-greifswald.de) provides detailed information on the genes and proteins of clinically and experimentally relevant S. aureus strains, currently covering NCTC 8325, COL, Newman, USA300 FPR3757, and N315. By implementing a pan-genome approach, AureoWiki facilitates the transfer of knowledge gained in studies with different S. aureus strains, thus supporting functional annotation and better understanding of this organism. All data related to a given gene or gene product is compiled on a strain-specific gene page. The gene pages contain sequence-based information complemented by data on, for example, protein function and localization, transcriptional regulation, and gene expression. The information provided is connected via links to other databases and published literature. Importantly, orthologous genes of the individual strains, which are linked by a pan-genome gene identifier and a unified gene name, are presented side by side using strain-specific tabs. The respective pan-genome gene page contains an orthologue table for 32 S. aureus strains, a multiple strain genome viewer, a protein sequence alignment as well as other comparative information. The data collected in AureoWiki is also accessible through various download options in order to support bioinformatics applications. In addition, based on two large-scale gene expression data sets, AureoWiki provides graphical representations of condition-dependent mRNA levels and protein profiles under various laboratory and infection-related conditions.