Electrochemical Evaluation of Nitroxyl Radical Catalysts and Electrochemical Detection of Cyclosporin A
Electrochemical Evaluation of Nitroxyl Radical Catalysts and Electrochemical Detection of Cyclosporin A
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DOI：
10.20964/2021.02.30
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发表时间：
2021-02-01
影响因子：
1.5
通讯作者：
Kashiwagi, Yoshitomo
中科院分区：
文献类型：
--
作者：
Komatsu, Sachiko;Sasano, Yusuke;Kashiwagi, Yoshitomo
硝基自由基催化剂在外加电位下氧化醇。由此产生的氧化电流可以量化酒精浓度。在这项工作中，我们评估了硝基自由基（或其对应的羟胺）在乙腈溶液中的催化活性，包括2,2,6,6-四甲基哌啶-1-氧基（TEMPO）作为代表性的硝基自由基，乙酰氨基-TEMPO（由于乙酰氨基基团而比TEMPO具有更高的氧化电位），AZADO， no -AZADO和NNO作为较少阻碍的双环硝基自由基，NHPI作为N，N-二酰基型羟胺)。考察了TEMPO、AZADO和NNO在有机溶剂中氧化醇类化合物的能力，并比较了它们的反应活性和电化学响应。活性最高的NNO用于含羟基药物环孢素A的电化学检测。摘要：陈述小说特点并引起人们注意小说新颖方面的摘要。
Nitroxyl radical catalysts oxidize alcohols under an applied electric potential. It is possible to quantify the alcohol concentration from the resulting oxidation current. In this work, we evaluated the catalytic activity of nitroxyl radicals (or their corresponding hydroxylamines), including 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) as representative nitroxyl radicals, acetoamido-TEMPO, which shows higher oxidation potential than TEMPO owing to the acetoamido group, AZADO, Nor-AZADO, and NNO as less-hindered bicyclic nitroxyl radicals, and NHPI as an N,N-diacyl-type hydroxylamine, in acetonitrile solution. TEMPO, AZADO and NNO were also evaluated for their ability to oxidize alcohols in organic solvents, and their reactivity was compared with the electrochemical response. The most active NNO was used for electrochemical detection of cyclosporin A, a drug with a hydroxyl group. An abstract stating the features and drawing attention to the novel aspects.