Glutinous rice amylopectin can adjust the plasma gut-regulated peptide levels in rhubarb-induced spleen deficiency rats
Glutinous rice amylopectin can adjust the plasma gut-regulated peptide levels in rhubarb-induced spleen deficiency rats
复制标题
糯米支链淀粉调节大黄脾虚大鼠血浆肠调节肽水平
DOI：
10.1039/c5fo00859j
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发表时间：
2016
期刊：
影响因子：
6.1
通讯作者：
Sun Baoguo
中科院分区：
文献类型：
--
作者：
Zhang Huijuan;Wang Jing;Liu Yingli;Sun Baoguo
通过测定大鼠血清胃泌素、胃动素、生长抑素等胃肠激素水平，观察糯米(GR)和支链淀粉(GRA)对脾虚大鼠胃肠的药理作用。GR和GRA分别以不同剂量的GR(7.5、15和30g/kg体重)和GRA(3.8、7.6和15g/kg体重)每天灌胃，连续4周。结果表明，与模型对照组相比，GRH高剂量组和GRA各剂量组大鼠最终体重均显著增加(P<；0.05)。与MC组相比，GR组和GRA组胃泌素含量(32.8-51.2%)、胃动素水平(13.8-39.2%)和淀粉酶含量(22.5-39.4%)均显著升高(P<；0.05)，GRH和GRA(GRAH)组生长抑素含量显著降低(P<；0.05)。同时，生长抑素水平与胃动素水平呈负相关(r=−0.964，P<0.01)，与淀粉酶水平呈负相关(r=−0.981，P<0.01)。GRAH治疗组大鼠最终体重、胃泌素含量、胃动素水平、淀粉酶含量最高，生长抑素含量最低，提示GRA可能在GR的调脾作用中起重要作用。
The pharmacological effects of glutinous rice (GR) and GR amylopectin (GRA) on the gastrointestine were investigated in rhubarb-induced spleen deficiency rats by determining the levels of gastrointestinal hormones such as the peptides serum gastrin, amylase motilin, and somatostatin. GR and GRA were given by gavage at various doses of GR (7.5, 15, and 30 g per kg body weight) and GRA (3.8, 7.6, and 15 g per kg body weight) every day for 4 weeks, respectively. The results indicated that the final body weight of rats in the highest-dose GR (GRH) group and all the GRA groups significantly (P < 0.05) increased (7.2–12.1%) compared with the model control (MC) group. All the GR and GRA treated groups had significantly (P < 0.05) higher gastrin contents (32.8–51.2%), motilin levels (13.8–39.2%), and amylase contents (22.5–39.4%) and the GRH and highest-dose GRA (GRAH) groups had significantly (P < 0.05) lower somatostatin contents compared with the MC group. Meanwhile, the somatostatin contents were negatively correlated with the motilin levels (r = −0.964, P < 0.01) and amylase contents (r = −0.981, P < 0.01). The GRAH treatment group had the highest final body weight, gastrin contents, motilin levels, and amylase contents and the lowest somatostatin contents, which demonstrated that GRA might play the most important role in the spleen-regulating activities of GR.