The correlation between HER-2 expression and the CEUS and ARFI characteristics of breast cancer.
The correlation between HER-2 expression and the CEUS and ARFI characteristics of breast cancer.
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乳腺癌HER-2表达与CEUS、ARFI特征的相关性
DOI：
10.1371/journal.pone.0178692
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Zhang B
中科院分区：
文献类型：
--
作者：
Wang XY;Hu Q;Fang MY;He Y;Wei HM;Chen XX;Zhang B
目的探讨乳腺癌超声造影（CEUS）和声辐射力脉冲（ARFI）特征与人表皮生长因子受体2 （HER-2）表达的关系。方法对167例明确诊断的乳腺癌肿瘤组织中HER-2的表达水平进行测定和分析。采用超声造影增强特征和时间强度曲线（TIC）、ARFI虚拟触摸组织成像（VTI）和虚拟触摸组织量化（VTQ）技术分析HER-2表达与乳腺癌超声造影和ARFI特征的关系。结果(1)不同HER-2表达水平研究组超声造影造影剂分布、穿支血流、过量程现象、灌注缺损等差异均有统计学意义（P < 0.05）。不同水平HER-2表达组间TIC峰值时间（PT）、上升支斜率(K)、曲线下面积（AUC）差异均有统计学意义（P < 0.05）。对比剂增强程度和TIC峰值强度（PI）与HER-2表达状态无关，差异无统计学意义（P < 0.05）。(2)不同HER-2表达水平组间VTQ结果差异有统计学意义（P < 0.05）。不同HER-2表达水平组间VTI图像特征差异无统计学意义（P < 0.05）。结论乳腺癌超声造影和ARFI特征与HER-2表达水平有相关性。这种相关性主要体现在灌注缺损、穿支血流、PI、PT、K和VTQ上。
Objective The purpose of the present study was to explore the correlation between the contrast-enhanced ultrasound (CEUS) and acoustic radiation force impulse (ARFI) characteristics of breast cancers and the expression of human epidermal growth factor receptor 2 (HER-2). Methods HER-2 expression levels in the tumor masses of 167 clearly diagnosed cases of breast cancer were measured and analyzed. The enhancement features and time intensity curve (TIC) of CEUS and virtual touch tissue imaging (VTI) and virtual touch tissue quantification (VTQ) technology of ARFI were employed to analyze the relationship between HER-2 expression and the CEUS and ARFI characteristics of breast cancer. Results (1) Statistically significant differences in the distribution of the contrast agent, perforator blood flow, the overranging phenomenon and perfusion defects between the study groups with different HER-2 expression levels (P < 0.05) were observed on CEUS. In addition, statistically significant differences in the TIC peak time (PT), slope of the ascending branch (K) and area under the curve (AUC) were found in the groups expressing different levels of HER-2 (P < 0.05). In contrast, the degree of contrast agent enhancement and TIC peak intensity (PI) were found to be independent of the expression status of HER-2, as they were not statistically significant (P > 0.05). (2) Statistically significant differences in the VTQ results between the groups with different HER-2 expression levels were found (P < 0.05). However, no statistically significant differences in VTI image characteristics were detected between the groups expressing different levels of HER-2 (P > 0.05). Conclusion A correlation was found between the CEUS and ARFI characteristics of breast cancer and HER-2 expression levels. This correlation was principally reflected in perfusion defects, perforator blood flow, PI, PT, K and VTQ.