A Neurobehavioral Intervention and Assessment Program in Very Low Birth Weight Infants: Outcome at 24 Months
A Neurobehavioral Intervention and Assessment Program in Very Low Birth Weight Infants: Outcome at 24 Months
复制标题
DOI：
10.1016/j.jpeds.2009.09.009
复制
发表时间：
2010-03-01
影响因子：
5.1
通讯作者：
Nollet, Frans
中科院分区：
文献类型：
--
作者：
Koldewijn, Karen;van Wassenaer, Aleid;Nollet, Frans
目的探讨婴儿行为评估与干预计划（IBAIP）是否能改善极低出生体重儿（VLBW）在24月龄时的发育和行为。研究设计：在一项多中心、随机、对照试验中，86名婴儿接受出院后干预，直至6个月矫正年龄。干预包括支持婴儿的自我调节和发展，促进敏感的亲子互动；90名对照组婴儿接受定期护理。6个月时，发现积极的干预效果。在24个月时，采用Bayley婴儿发育量表- ii （BSID-II）和儿童行为检查表（CBCL）评估发育和行为。结果干预组患儿83例，对照组患儿78例。在调整围生期特征差异后，心理运动发育指数的干预效果为6.4分（±标准误差2.4分）。各组在精神发展指数、BSID-II行为评定量表或CBCL上没有差异。亚组分析显示，患有支气管肺发育不良并伴有生物和社会风险因素的干预婴儿的运动和心理结果均有所改善。结论IBAIP显示VLBW婴儿的运动改善持续到2岁矫正年龄。[J] .儿科杂志2010；56:359-65。
Objective To determine whether the Infant Behavioral Assessment and Intervention Program (IBAIP) improves development and behavior in very low birth weight (VLBW) infants at 24-month corrected age.Study design In a multicenter, randomized, controlled trial 86 infants received postdischarge intervention until 6-month corrected age. The intervention consisted of supporting infants' self-regulation and development, and facilitating sensitive parent-infant interactions; 90 control infants received regular care. At 6 months, positive intervention effects were found. At 24 months, development and behavior were evaluated with the Bayley Scales of Infant Development-II (BSID-II) and the Child Behavior Check List (CBCL).Results Eighty-three intervention and 78 control infants were available for follow-up. After adjustment for differences in perinatal characteristics, an intervention effect of 6.4 points (+/- standard error, 2.4) on the Psychomotor Developmental Index favored the intervention infants. Groups did not differ on the Mental Developmental Index, the Behavioral Rating Scale of the BSID-II, or on the CBCL. Subgroup analyses revealed improved motor as well as improved mental outcomes in intervention infants with bronchopulmonary dysplasia and with combined biological and social risk factors.Conclusions The IBAIP shows sustained motor improvement in VLBW infants until 2-year corrected age. (J Pediatr 2010;156:359-65).