Androgen treatment and muscle strength in elderly men: A meta-analysis
Androgen treatment and muscle strength in elderly men: A meta-analysis
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DOI：
10.1111/j.1532-5415.2006.00938.x
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发表时间：
2006-11-01
影响因子：
6.3
通讯作者：
Ostir, Glenn V.
中科院分区：
文献类型：
--
作者：
Ottenbacher, Kenneth J.;Ottenbacher, Margaret E.;Ostir, Glenn V.
回顾已发表的研究雄激素治疗对老年男性肌肉力量影响的随机试验，采用荟萃分析程序进行系统评价，计算机和手动检索，检索MEDLINE、EMBASE、CINAHL和科克伦注册中心的试验。关键词包括睾酮、雄激素、肌肉减少症、肌肉丢失、老年、衰老、老年人、老年人、随机对照试验和对照临床试验。共发现65项非重叠研究，采用荟萃分析方法对11项随机、双盲试验进行评价。这些试验为65岁及以上健康男性的替吉奥或双氢睾酮（DHT）替代疗法。肌力试验。这些研究包括38项统计学比较。根据样本量调整的平均g指数（g（i））为0.53（95%置信区间（CI）= 0.21-0.86）。亚组分析显示，下肢肌力指标（g（i）= 0.63，95% CI = 0.03-1.28）的影响大于上肢肌力指标（g（i）= 0.47，95% CI = 0.12-0.84）。睾酮/DHT注射给药的平均g指数（g（i）= 0.95，95% CI = 0.33-1.58）大于局部给药（g（i）= 0.26，95% CI = 0.08-0.42）或口服给药（g（i）=-0.21，95% CI = -1.40-1.02）。效应量与研究特征有关，如受试者流失和设计质量评级。敏感性分析显示，剔除一项研究后，平均g指数从0.53降至0.23。结果表明，睾酮/DHT治疗在11项随机试验中的男性中产生了肌肉力量的适度增加。一项研究影响了平均效应量。
To review published, randomized trials examining the effect of androgen treatment on muscle strength in older men.Systematic review using meta-analysis procedures.Computerized and manual searches.MEDLINE, EMBASE, CINAHL, and the Cochrane Register were searched for trials. Key words included testosterone, androgen, sarcopenia, muscle loss, aged, aging, elderly, older, geriatric, randomized controlled trials, and controlled clinical trials. Sixty-five nonoverlapping studies were found. Meta-analysis methods were used to evaluate the 11 randomized, double-blind trials.Testosterone or dihydrotestosterone (DHT) replacement therapy in healthy men aged 65 and older.Tests of muscle strength.The studies included 38 statistical comparisons. The mean g-index (g(i)) adjusted for sample size was 0.53 (95% confidence interval (CI) = 0.21-0.86). Subanalyses revealed larger effects for measures of lower extremity muscle strength (g(i) = 0.63, 95% CI = 0.03-1.28) than for upper extremity muscle strength (g(i) = 0.47, 95% CI = 0.12-0.84). A larger mean g-index was found for injected (g(i) = 0.95, 95% CI = 0.33-1.58) than topical (g(i) = 0.26, 95% CI = 0.08-0.42) or oral (g(i) = -0.21, 95% CI = -1.40-1.02) administration of testosterone/DHT. Effect sizes were related to study characteristics such as subject attrition and design-quality ratings. Sensitivity analyses revealed that the elimination of one study reduced the mean g-index from 0.53 to 0.23.The results suggest that testosterone/DHT therapy produced a moderate increase in muscle strength in men participating in 11 randomized trials. One study influenced the mean effect size.