Anseculin improves passive avoidance learning of aged mice.
Anseculin improves passive avoidance learning of aged mice.
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DOI：
10.1016/s1043-6618(02)00311-0
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发表时间：
2003-03
影响因子：
9.3
通讯作者：
J. Knauber;Walter E. Müller
中科院分区：
文献类型：
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作者：
J. Knauber;Walter E. Müller
Anseculin 是一种新型香豆素衍生物，具有改善认知功能的前景。我们研究了它对年轻和老年小鼠被动回避学习的可能影响以及与其 α1 拮抗特性的可能关系。单剂量的安克林不会影响年轻和老年小鼠的长期记忆。此外，在年轻小鼠中，使用安克林进行亚慢性治疗对认知功能没有影响，而老年、认知受损的小鼠明显表现出长期记忆得到改善，而对短期记忆没有影响。对老年对照小鼠的进一步生化研究表明，与年轻小鼠相比，中枢 α1 肾上腺素受体密度显着降低，但 α1 肾上腺素受体介导的 IP 水解作用未发生变化。安克林亚慢性治疗对年轻成年小鼠中枢 α1 肾上腺素受体的密度没有影响，对认知障碍老年小鼠的密度只有很小但不显着的影响。此外，anseculin 对 α1-肾上腺素受体介导的 IP 水解没有影响。
Anseculin is a new coumarine derivative with promising cognition improving properties. We investigated its possible effects on passive avoidance learning in young and aged mice and the possible relationship to its α1-antagonistic properties. A single dose of anseculin did not affect long-term memory of young and aged mice. Moreover, in young mice, subchronic treatment with anseculin had no effect on cognitive functions, whereas aged, cognitively impaired mice clearly showed improved long-term memory with no effects on short-term memory. Further biochemical studies of aged control mice showed in comparison to the young mice a significant decrease of central α1-adrenoceptors density, but unchanged α1-adrenoceptor-mediated IP hydrolysis. Subchronic treatment with anseculin had no effect on the density of central α1-adrenoceptors in young adult mice and only a small although not significant effect on the density of cognitively-impaired aged mice. Furthermore, anseculin has no effects on α1-adrenoceptor-mediated IP hydrolysis.