RECEDING HORIZON CONTROL METHOD APPLIED TO ANTIVIRAL TREATMENT OF AIDS

RECEDING HORIZON CONTROL METHOD APPLIED TO ANTIVIRAL TREATMENT OF AIDS
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后退控制方法在艾滋病抗病毒治疗中的应用

DOI:
10.18514/mmn.2004.83
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发表时间:
2004
期刊:
影响因子:
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通讯作者:
A. Elaiw
A. Elaiw
中科院分区:
--
文献类型:
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作者:
A. Elaiw

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本文研究了一个描述免疫系统(CD4细胞和细胞毒性T淋巴细胞CTL)与人类免疫缺陷病毒HIV相互作用的模型的期望平衡点的稳定性。控制变量是药物剂量。考虑了两种抗HIV药物:1种逆转录酶抑制剂(RTI)和2种蛋白酶抑制剂(PI)。该控制器是由滚动时域控制(RHC)方法的一个变种。我们使用由(3)得到的结果,给出了足够的条件,该条件保证对于足够小的离散化参数,使近似离散时间模型稳定的滚动时域控制器也使精确离散时间模型稳定。模拟结果进行了讨论。数学科目分类:93D15、93C57、92D30
This paper investigates the stabilization of a desired equilibrium point of a model describing the interaction of the immune system (CD4 cells and cyto- toxic T lymphocytes CTL) with human immunodeficiecy virus HIV with sampled- data controllers. The control variable is the drug dose. Two cases of anti-HIV drugs are considered: 1 reverse transcriptase inhibitors (RTI), and 2 protease in- hibitors (PI). The controller is constructed by a variant of the receding horizon con- trol (RHC) method. We use the results obtained by (3) giving su cient conditions which guarantee that the receding horizon controller that stabilizes the approximate discrete-time model also stabilizes the exact discrete-time model for su ciently small discretization parameters. Results of simulations are discussed. Mathematics Subject Classification: 93D15, 93C57, 92D30
非线性采样数据系统的后退时限H_∞控制
DOI: --
发表时间: 2006
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影响因子: --
作者:
片山仁志;市川朗
通讯作者: 市川朗