Zinc protoporphyrin. Past, present, and future.
Zinc protoporphyrin. Past, present, and future.
复制标题
原卟啉锌。
DOI：
10.1111/j.1749-6632.1987.tb48755.x
复制
发表时间：
1987
影响因子：
5.2
通讯作者：
Turnlund,JR
中科院分区：
文献类型：
--
作者：
Labbé,RF;Rettmer,RL;Shah,AG;Turnlund,JR
锌原卟啉研究在几个方面的进展越来越快。现在综合考虑的各种生化和临床证据表明，在相对缺铁的红细胞生成状态和铅抑制的铁代谢状态下，亚铁螯合酶催化锌原卟啉的形成。此外，根据铁耗尽最早状态期间的变化，重新定义了锌原卟啉与铁状态的某些其他参数的关系。这些临床研究表明，锌原卟啉水平和铁蛋白水平一致变化，但转铁蛋白饱和度百分比和血细胞比容结果的变化不太一致。因此，锌原卟啉和铁蛋白在代谢上密切相关，使得缺铁性红细胞生成成为铁耗竭的最初表现。结果的测量和表达为摩尔锌原卟啉/摩尔血红素提高了结果的质量，部分原因是消除了现有仪器中设计的假设血细胞比容。血液荧光测定技术的其他改进使得锌原卟啉测量的潜在广泛应用得以探索，用于铅监测和诊断、血库、儿科、产科、运动医学和其他需要非常灵敏、经济有效的铁状态指示的临床情况。
The course of zinc protoporphyrin research has progressed at an increasingly rapid pace on several fronts. A variety of biochemical and clinical evidence viewed in toto now suggests that ferrochelatase catalyzes zinc protoporphyrin formation in states of relative iron-deficient erythropoiesis and in lead-inhibited iron metabolism. Furthermore, a redefinition of the relationship of zinc protoporphyrin to certain other parameters of iron status has been made based upon changes during the earliest states of iron depletion. These clinical studies show that the zinc protoporphyrin level and the ferritin level vary in concert but that changes in the percent transferrin saturation and in the hematocrit results are less consistent. Thus zinc protoporphyrin and ferritin are closely linked metabolically such that iron-deficient erythropoiesis becomes an initial manifestation of iron depletion. The measurement and expression of results as mumoles zinc protoporphyrin/mole heme have improved the quality of results, partly by the elimination of the assumed hematocrit designed into existing instruments. Other refinements in hematofluorometry technology have permitted exploration of the potentially extensive applications of zinc protoporphyrin measurements for lead surveillance and diagnosis, blood banking, pediatrics, obstetrics, sports medicine, and other clinical situations where a very sensitive, cost-effective indication of iron status is required.