The correlation between retinal sensitivity assessed by microperimetry and contrast sensitivity in diabetic macular oedema
The correlation between retinal sensitivity assessed by microperimetry and contrast sensitivity in diabetic macular oedema
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DOI：
10.1136/bjophthalmol-2013-304765
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发表时间：
2014-12-01
影响因子：
4.1
通讯作者：
Huh, Kuhl
中科院分区：
文献类型：
--
作者：
Kim, Young Ho;Yun, Cheolmin;Huh, Kuhl
目的探讨糖尿病视网膜病变（DR）合并黄斑水肿（CSME）患者对比敏感度（CS）与微视野（MP）视网膜敏感度（RS）的关系。用光谱SD-光学相干地形图/扫描激光检眼镜系统测量视网膜厚度（RT）和MP。测量中心凹中心1 mm区（CRT）和注视中心1 mm区（FCRT）的平均中心RT。在注视中心、2度和4度区域内测试RS。用对比度眩光测试仪测量了6种靶大小（6.3 °、4.0 °、2.5 °、1.6 °、1.0 °、0.64 °）的CS。6种靶尺寸的平均log CS（-log 10）范围为0.19 - 1.32。注视中心、2度内和4度区域内的平均RS分别为8.51 +/- 4.81 dB、8.58 +/- 3.88 dB和9.22 +/- 3.56 dB。所有测试区域的RS与所有目标尺寸的log CS显著相关（范围，r=0.366-0.755; p=0.0001-0.030）。CRT和FCRT与log CS或RS无显著相关性。结论CS和RS在CSME中具有中等程度的相关性。然而，CS和RS与CSME患者的RT均不相关。这可能是CS和MP是互补的，是有用的工具，在功能性视觉的评价。
Aim To investigate the relationship between contrast sensitivity (CS) and retinal sensitivity (RS) assessed by microperimetry (MP) in diabetic retinopathy (DR) with clinically significant macular oedema (CSME).Methods A retrospective study was performed with 35 eyes of 35 patients with DR and CSME. Retinal thickness (RT) and MP were tested with the spectral SD-optical coherence topography/scanning laser ophthalmoscope system. Mean central RT at the fovea centre's 1 mm zone (CRT) and at the fixation centre's 1 mm zone (FCRT) was measured. RS was tested at the fixation centre, within 2 degrees and 4 degrees areas. CS was measured with six target sizes (6.3 degrees, 4.0 degrees, 2.5 degrees, 1.6 degrees, 1.0 degrees, 0.64 degrees) with a contrast glare tester.Results The mean CRT and FCRT were 344.3 +/- 136.2 and 359.9 +/- 135.5 mu m, respectively. Mean log CSs (-log10) with the six target sizes ranged from 0.19 to 1.32. The mean RS at the fixation centre, within 2 degrees, and within 4 degrees area were 8.51 +/- 4.81 dB, 8.58 +/- 3.88 dB and 9.22 +/- 3.56 dB, respectively. RS at all tested areas were significantly correlated to log CS with all target sizes (range, r=0.366-0.755; p=0.0001-0.030). CRT and FCRT were not significantly correlated to log CS or RS.Conclusions CS and RS showed moderately significant correlations in CSME. However, neither CS nor RS was correlated with RT in patients with CSME. It could be that CS and MP are complementary to each other and are useful tools in the evaluation of functional vision.