Mechanisms of interaction of extremely low frequency electric fields and biological systems
Mechanisms of interaction of extremely low frequency electric fields and biological systems
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DOI：
10.1093/oxfordjournals.rpd.a006364
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发表时间：
2003-01-01
影响因子：
1
通讯作者：
Foster, KR
中科院分区：
文献类型：
--
作者：
Foster, KR
本文回顾了极低频 (ELF) 场与生物系统之间的相互作用机制。重点是简单的定量模型，并辅以更详细的计算机分析结果。回顾了尺度关系，它是外部场与身体内部耦合以及细胞外场与细胞膜中诱导的电位耦合的基础。基于 Reilly 的工作，回顾了刺激可兴奋组织的时域和频率阈值之间的关系。针对生物系统中弱 ELF 场可能产生的影响问题，回顾了一系列热和非热相互作用机制。每种机制的特点是阈值场强（低于该阈值，不会产生可观察到的响应）和动力学；在每种情况下，产生可观察效应的预期原位组织强度远远高于本综述中考虑的“弱”场范围。然而，许多地方的生物效应文献尚不清楚，有许多关于弱场效应的可能机制的猜测，并且许多关于效应的报告无法根据本文讨论的机制清楚地解释。
This article reviews mechanisms of interaction between extremely-low frequency (ELF) fields and biological systems. The emphasis is on simple quantitative models, supplemented by results of more detailed computer analysis. Scaling relations are reviewed which underlie the coupling of external fields to the inside of the body, and of extracellular fields to potentials induced in cell membranes. The relation between time domain and frequency thresholds for stimulating excitable tissues is reviewed, based on the work of Reilly. A range of thermal and non-thermal interaction mechanisms are reviewed, with respect to the question of possible effects of weak ELF fields in biological systems. Each mechanism is characterised by a threshold field strength (below which no observable response is produced) and dynamics; in each case, the anticipated in situ tissue strengths for producing observable effects are far higher than the range of 'weak' fields considered in this review. However, the bioeffects literature is unclear in many places, with numerous speculations about possible mechanisms for weak field effects and many reports of effects that are not clearly interpretable in terms of the mechanisms discussed in this article.