A preliminary study of dopamine transporter binding in bipolar and unipolar depressed patients and healthy controls
A preliminary study of dopamine transporter binding in bipolar and unipolar depressed patients and healthy controls
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DOI：
10.1159/000106476
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发表时间：
2007-01-01
影响因子：
3.2
通讯作者：
Newberg, Andrew B.
中科院分区：
文献类型：
--
作者：
Amsterdam, Jay D.;Newberg, Andrew B.
目的：我们检查了双相和单相抑郁患者的纹状体多巴胺转运蛋白 (DAT) 结合，并将这些值与使用选择性 DAT 放射性配体 [Tc-99m]TRODAT-1 和单光子发射计算机断层扫描成像从健康对照受试者获得的值进行比较。我们假设双相情感障碍患者的 DAT 水平可能高于单相情感障碍患者。方法：从 5 名双相情感障碍患者和 10 名单相情感障碍患者以及 46 名健康对照中获取 [Tc-99m]TRODAT-1 扫描。计算纹状体中感兴趣区域的 [Tc-99m]TRODAT-1 结合亲和力的分布体积比 (DVR)。结果：与对照组相比，双相情感障碍患者右后壳核 (p = 0.001) 和左尾状核区域 (p = 0.007) 的 DVR 值更高。与单相患者相比，双相患者在所有检查的大脑区域中 DAT 结合率均稍低，并且右侧尾状核区域的 DVR 显着较低 (p = 0.05)。结论：这些数据表明，与对照组相比，双相和单相抑郁患者的纹状体 DAT 密度可能增加，并且双相和单相抑郁患者的纹状体 DAT 结合模式可能不同。版权所有 (c) 2007 S. Karger AG，巴塞尔。
Objective: We examined striatal dopamine transporter (DAT) binding in bipolar and unipolar depressed patients and compared these values to those obtained from healthy control subjects using the selective DAT radioligand [Tc-99m]TRODAT-1 and single photon emission computed tomography imaging. We hypothesized that DAT levels might be higher in bipolar versus unipolar patients. Methods: [Tc-99m]TRODAT-1 scans were acquired from 5 bipolar and 10 unipolar patients and from 46 healthy controls. Distribution volume ratio (DVR) of [Tc-99m]TRODAT-1 binding affinity was calculated for regions of interest in the striatum. Results: Bipolar patients had greater DVR values compared to controls in the right posterior putamen (p = 0.001) and in the left caudate region (p = 0.007). Bipolar patients had modestly lower DAT binding in all brain regions examined, and a significantly lower DVR in the right caudate region compared to unipolar patients (p = 0.05). Conclusion: These data suggest that striatal DAT density may be increased in bipolar and unipolar depressed patients compared to controls, and that bipolar and unipolar depressed patients may have a different pattern of striatal DAT binding. Copyright (c) 2007 S. Karger AG, Basel.