ALTERED PHOSPHATE-METABOLISM IN MYOCARDIAL-INFARCTION - P-31 MR SPECTROSCOPY
ALTERED PHOSPHATE-METABOLISM IN MYOCARDIAL-INFARCTION - P-31 MR SPECTROSCOPY
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DOI：
10.1148/radiology.165.3.2961004
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发表时间：
1987-12-01
期刊：
影响因子：
19.7
通讯作者：
BASHORE, TM
中科院分区：
文献类型：
--
作者：
BOTTOMLEY, PA;HERFKENS, RJ;BASHORE, TM
对4例急性前壁心肌梗死患者冠脉成形术及药物治疗后的高能心肌磷代谢进行了心门磁共振(MR)深度分辨表面线圈波谱(DRESS)检测。与心外膜移位频谱和7名健康志愿者(P<；0.05)相比，心内膜或跨壁磁共振频谱的磷酸肌酸(PC)/无机磷(PI)比值显著降低(约三倍)，PI与三磷酸腺苷(ATP)的比值显著升高(P<；0.05)。在健康志愿者的心脏周期中，高能磷酸盐代谢产物和PI比率没有显著变化。然而，包括血液2，3-二磷酸甘油酸酯在内的磷单酯成分对PI共振的污染，阻碍了PI和pH的准确光谱定量。结果表明，P-31MR波谱可直接用于临床心肌梗死时细胞能量储备的评估和代谢反应的评估。
The high-energy myocardial phosphate metabolism of four patients with acute anterior myocardial infarction after coronary angioplasty and drug therapy was evaluated with cardiac-gated phosphorus magnetic resonance (MR) depth-resolved surface coil spectroscopy (DRESS) 5-9 days after the onset of symptoms. Significant reductions (about threefold) in the phosphocreatine (PCr) to inorganic phosphate (Pi) ratio and elevations in the Pi to adenosine triphosphate (ATP) ratio were observed in endocardially or transmurally derived MR spectra when compared with values from epicardially displaced spectra and values from seven healthy volunteers (P < .05). High-energy phosphate metabolites and Pi rations did not vary significantly during the cardiac cycle in healthy volunteers. However, contamination of Pi resonances by phosphomonoester components, including blood 2,3-diphosphoglycerate, precluded accurate spectral quantifications of Pi and pH. The results indicate that localized P-31 MR spectroscopy may be used to directly assess cellular energy reserve in clinical myocardial infarction and to evaluate metabolic response to interventions.