Transcriptional regulatory networks for CD4 T cell differentiation.
Transcriptional regulatory networks for CD4 T cell differentiation.
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DOI：
10.1007/82_2014_372
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发表时间：
2014
影响因子：
--
通讯作者：
Zhu J
中科院分区：
文献类型：
--
作者：
Christie D;Zhu J
CD4+ T细胞通过分泌细胞因子激活靶细胞，在控制适应性免疫应答中发挥核心作用。Naïve CD4+ T细胞分化为至少四个亚群，Th1、Th2、Th17和诱导调节性T细胞，每个亚群都具有独特的病原体消除功能。这些亚群的分化是在细胞因子刺激下诱导的，细胞因子刺激转化为Stat激活，随后是主调控转录因子的诱导。除了这些因子外，多种其他的转录因子，包括亚群特异性的和共享的，也参与促进亚群分化。本文将重点介绍控制CD4+ T细胞分化的转录因子网络。
CD4+ T cells play a central role in controlling the adaptive immune response by secreting cytokines to activate target cells. Naïve CD4+ T cells differentiate into at least four subsets, Th1, Th2, Th17, and inducible regulatory T cells, each with unique functions for pathogen elimination. The differentiation of these subsets is induced in response to cytokine stimulation, which is translated into Stat activation, followed by induction of master regulator transcription factors. In addition to these factors, multiple other transcription factors, both subset specific and shared, are also involved in promoting subset differentiation. This review will focus on the network of transcription factors that control CD4+ T cell differentiation.