Multifactorial Relationship Between 18F-Fluoro-Deoxy-Glucose Positron Emission Tomography Signaling and Biomechanical Properties in Unruptured Aortic Aneurysms
Multifactorial Relationship Between 18F-Fluoro-Deoxy-Glucose Positron Emission Tomography Signaling and Biomechanical Properties in Unruptured Aortic Aneurysms
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DOI：
10.1161/circimaging.112.000415
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发表时间：
2014-01-01
影响因子：
7.5
通讯作者：
Sakalihasan, Natzi
中科院分区：
文献类型：
--
作者：
Nchimi, Alain;Cheramy-Bien, Jean-Paul;Sakalihasan, Natzi
Background The relationship between biomechanical properties and biological activities in aortic aneurysms was investigated with finite element simulations and F-18-fluoro-deoxy-glucose (F-18-FDG) positron emission tomography.Methods and Results The study included 53 patients (45 men) with aortic aneurysms, 47 infrarenal (abdominal aortic) and 6 thoracic (thoracic aortic), who had 1 F-18-FDG positron emission tomography/computed tomography. During a 30-month period, more clinical events occurred in patients with increased F-18-FDG uptake on their last examination than in those without (5 of 18 [28%] versus 2 of 35 [6%]; P=0.03). Wall stress and stress/strength index computed by finite element simulations and F-18-FDG uptake were evaluated in a total of 68 examinations. Twenty-five (38%) examinations demonstrated 1 aneurysm wall area of increased F-18-FDG uptake. The mean number of these areas per examination was 1.6 (18 of 11) in thoracic aortic aneurysms versus 0.25 (14 of 57) in abdominal aortic aneurysms, whereas the mean number of increased uptake areas colocalizing with highest wall stress and stress/strength index areas was 0.55 (6 of 11) and 0.02 (1 of 57), respectively. Quantitatively, F-18-FDG positron emission tomographic uptake correlated positively with both wall stress and stress/strength index (P
