DORSOLATERAL PREFRONTAL CORTEX STIMULATION MODULATES ELECTROCORTICAL MEASURES OF VISUAL ATTENTION: EVIDENCE FROM DIRECT BILATERAL EPIDURAL CORTICAL STIMULATION IN TREATMENT-RESISTANT MOOD DISORDER
DORSOLATERAL PREFRONTAL CORTEX STIMULATION MODULATES ELECTROCORTICAL MEASURES OF VISUAL ATTENTION: EVIDENCE FROM DIRECT BILATERAL EPIDURAL CORTICAL STIMULATION IN TREATMENT-RESISTANT MOOD DISORDER
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DOI：
10.1016/j.neuroscience.2010.04.069
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发表时间：
2010-09-29
期刊：
影响因子：
3.3
通讯作者：
Nahas, Z.
中科院分区：
文献类型：
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作者：
Hajcak, G.;Anderson, B. S.;Nahas, Z.
皮层电活动越来越多地用于研究情绪调节和认知控制对视觉刺激神经反应的影响。在当前的研究中，我们使用直接硬膜外皮质刺激（EpCS）来检测PFC刺激对顶叶最大晚正电位（LPP）的区域特异性，LPP是一种事件相关电位（ERP）生物标志物，用于视觉对显著刺激的注意。在5例难治性情绪障碍患者的双侧额极（FP）和背外侧（DL）前额叶皮层上立体定向植入刺激电极。在激活的第一天，患者接受了假控制的EpCS加上64通道脑电图（EEG）记录和被动观看厌恶和中性图像。除假手术外，患者在观看中性和厌恶图片时，前额叶前部皮层受到2伏或4伏的刺激。在假性条件下，与中性刺激相比，厌恶刺激的LPP更大(F(1,4)=232.07， P
Electrocortical activity is increasingly being used to study emotion regulation and the impact of cognitive control on neural response to visual stimuli. In the current study, we used direct epidural cortical stimulation (EpCS) to examine regional specificity of PFC stimulation on the parietally-maximal late positive potential (LPP), an event-related potential (ERP) biomarker of visual attention to salient stimuli. Five patients with treatment-resistant mood disorders were stereotactically implanted with stimulating paddles over frontopolar (FP) and dorsolateral (DL) prefrontal cortex bilaterally. On their first day of activation, patients underwent sham-controlled EpCS coupled with 64-channel electroencephalograph (EEG) recordings and passive viewing of aversive and neutral images. In addition to sham, patients had either FP or DL prefrontal cortex stimulated at 2 or 4 V while they viewed neutral and aversive pictures. As expected during the sham condition, LPP was larger for aversive compared to neutral stimuli (F(1,4)=232.07, P