Alisma orientale: Ethnopharmacology, Phytochemistry and Pharmacology of an Important Traditional Chinese Medicine
Alisma orientale: Ethnopharmacology, Phytochemistry and Pharmacology of an Important Traditional Chinese Medicine
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泽泻：重要中药的民族药理学、植物化学和药理学
DOI：
10.1142/s0192415x16500142
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发表时间：
2016-04-01
影响因子：
5.7
通讯作者：
Zheng, Chengjian
中科院分区：
文献类型：
--
作者：
Shu, Zhiheng;Pu, Jiang;Zheng, Chengjian
东方泽泻[Alisma orientale(Sam.)朱泽普。泽泻科(Zismataceae)是一种传统的著名中草药。其根茎具有多种生物活性，常用于治疗少尿、浮肿、淋病尿浊、白带、腹泻、头晕等。从侧柏中分离得到约120个化合物。侧柏中的萜类化合物已被鉴定为其特征成分，其中包括原烷三萜和愈创木倍半萜。现代药理研究表明，侧柏及其活性成分具有广泛的生物活性，如利尿、抗尿路结石、抗肾小球肾炎、抗动脉粥样硬化、免疫调节、保肝等。侧柏的药用潜力使其成为新药开发的理想候选者。鉴定其生物活性成分，阐明其构效关系和详细的作用机制还需要进一步的研究。此外，利用侧柏的其他药用部位可以减少资源浪费，并提供新的次生代谢物。
Alisma orientale (Sam.) Juzep. (Alismataceae) is a traditional and famous Chinese medicinal herb. Its rhizomes, which possess versatile bioactivities, are commonly used to treat oliguria, edema, gonorrhea with turbid urine, leukorrhea, diarrhea and dizziness. Approximately 120 compounds have been isolated from A. orientale. Terpenoids have been identified as A. orientale's characteristic constituents, which include protostane triterpenoids and guaiane sesquiterpenoids. The traditional medical uses of A. orientale in TCM have been evaluated in modern pharmacological studies, which have shown that A. orientale and its active constituents exhibit a wide range of bioactivities, such as diuretic, anti-urolithiatic, antinephritic, anti-atherosclerotic, immunomodulatory, and hepatoprotective activities. The medicinal potential of A. orientale makes it an ideal candidate for new drug development. Further studies are still required to identify its bioactive constituents, and elucidate the structure-activity relationship and detailed mechanisms of action. Additionally, the use of the other medicinal parts of A. orientale may reduce resource waste and afford novel secondary metabolites.