REPRODUCTIVE CAPACITY OF AGING FEMALE RATS
REPRODUCTIVE CAPACITY OF AGING FEMALE RATS
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DOI：
10.1159/000122367
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发表时间：
1975-01-01
影响因子：
4.1
通讯作者：
MEITES, J
中科院分区：
文献类型：
--
作者：
HUANG, HH;MEITES, J
观察到20个月或更大的经产雌性Long-Evans大鼠从不规则的发情周期进展到恒定发情综合征，再到一系列不规则的假性妊娠，最后到无发情状态。持续发情的动物的特征是卵巢发育良好，有时有囊性卵泡，无黄体，雌激素刺激的子宫，垂体前叶正常。反复假孕大鼠有长时间的不动情期，卵巢有许多黄体，子宫有许多分泌腺，垂体前叶经常显示出血或小肿瘤区域。麻醉大鼠卵巢小，萎缩，无明显卵泡或黄体成分，子宫萎缩，垂体瘤大。每天两次注射左旋多巴诱导恢复正常或不规则的发情周期在大多数恒定的发情，但不是在假孕或anestrous大鼠。
Multiparous female Long-Evans rats, 20 months or older, were seen to progress from irregular estrous cycles to a constant-estrous syndrome to a series of irregular pseudopregnancies to an anestrous state. An animal in constant estrus was characterized by ovaries with well developed and sometimes cystic follicles, no corpora lutea, an estrogen-stimulated uterus, and an anterior pituitary that appeared normal. Repeatedly pseudopregnant rats had long diestrous periods of variable length, ovaries with many corpora lutea, uteri with numerous secretory glands, and anterior pituitaries that often showed hemorrhagic or small tumorous areas. Anestrous rats had small, atrophic ovaries with no obvious follicular or luteal elements, atrophic uteri, and large pituitary tumors. Twice-daily injections of L-dopa induced the resumption of regular or irregular estrous cycles in most constant-estrous but not in pseudopregnant or anestrous rats.