Glaucoma patients demonstrate faulty autoregulation of ocular blood flow during posture change
Glaucoma patients demonstrate faulty autoregulation of ocular blood flow during posture change
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DOI：
10.1136/bjo.83.7.809
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发表时间：
1999-07-01
影响因子：
4.1
通讯作者：
Kagemann, L
中科院分区：
文献类型：
--
作者：
Evans, DW;Harris, A;Kagemann, L
背景/目的-体位改变时血流的自动调节对保证器官循环的一致性很重要。本研究的目的是比较青光眼患者和正常人在仰卧位和直立位时球后眼血流的变化。方法20例开角型青光眼患者和20例正常人，年龄和性别分布相似，进行了评估。血压，眼内压，和球后血流速度进行了测试后，坐了30分钟，躺了30分钟后再次。采用彩色多普勒成像（CDI）测量眼动脉和视网膜中央动脉的收缩期峰值流速（PSV）、舒张末期流速（EDV）和阻力指数（RI）。正常受试者显示OA EDV显著增加（p = 0.016），OA RI（p = 0.0006）和CRA RI（p = 0.016）显著降低。青光眼患者表现出类似的变化，在OA措施EDV（p = 0.02）和RI（p = 0.04），但没有变化CRA measurements.Conclusion-Glaucoma患者表现出错误的视网膜中央动脉血流自动调节的姿势变化。
Background/aims-Autoregulation of blood flow during posture change is important to ensure consistent organ circulation. The purpose of this study was to compare the change in retrobulbar ocular blood flow in glaucoma patients with normal subjects during supine and upright posture.Methods-20 open angle glaucoma patients and 20 normal subjects, similar in age and sex distribution, were evaluated. Blood pressure, intraocular pressure, and retrobulbar blood velocity were tested after 30 minutes of sitting and again after 30 minutes of lying. Retrobulbar haemodynamic measures of peak systolic velocity (PSV), end diastolic velocity (EDV), and resistance index (RI) were obtained in the ophthalmic and central retinal arteries using colour Doppler imaging (CDI).Results-When changing from the upright to supine posture, normal subjects demonstrated a significant increase in OA EDV (p = 0.016) and significant decrease in OA RI (p = 0.0006) and CRA RI (p = 0.016). Glaucoma patients demonstrated similar changes in OA measures of EDV (p = 0.02) and RI (p = 0.04), but no change in CRA measures.Conclusion-Glaucoma patients exhibit faulty autoregulation of central retinal artery blood flow during posture change.