TRANSCompel®:: a database on composite regulatory elements in eukaryotic genes
TRANSCompel®:: a database on composite regulatory elements in eukaryotic genes
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DOI：
10.1093/nar/30.1.332
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发表时间：
2002-01-01
影响因子：
14.9
通讯作者：
Wingender, E
中科院分区：
文献类型：
--
作者：
Kel-Margoulis, OV;Kel, AE;Wingender, E
TRANSCompel®数据库源自COMPEL，它强调转录因子与其靶位点结合之间特定相互作用的关键作用，这些相互作用在特定细胞环境中提供了基因调控的特定特征。复合调控元件包含两个位置相近的不同转录因子结合位点，是提供组合式转录调控的最小功能单位。特定的因子 - DNA和因子 - 因子相互作用都对复合元件（CEs）的功能有贡献。有关已知复合元件的结构以及通过此类复合元件实现的特定基因调控的信息，对于启动子预测、基因功能预测以及应用基因工程似乎都极为有用。每个数据库条目对应于特定基因内的一个单独的复合元件，并包含两个结合位点、两个相应的转录因子以及证实转录因子之间协同作用的实验信息。配备搜索和浏览工具的COMPEL数据库可在http://www.gene - regulation.com/pub/databases.html#transcompel获取。此外，我们还开发了用于在DNA序列中搜索潜在复合元件的CATCH™程序。它可在http://compel.bionet.nsc.ru/FunSite/CompelPatternSearch.html作为CompelPatternSearch免费获取。
Originating from COMPEL, the TRANSCompel((R)) database emphasizes the key role of specific interactions between transcription factors binding to their target sites providing specific features of gene regulation in a particular cellular content. Composite regulatory elements contain two closely situated binding sites for distinct transcription factors and represent minimal functional units providing combinatorial transcriptional regulation. Both specific factor-DNA and factor-factor interactions contribute to the function of composite elements (CEs). Information about the structure of known CEs and specific gene regulation achieved through such CEs appears to be extremely useful for promoter prediction, for gene function prediction and for applied gene engineering as well. Each database entry corresponds to an individual CE within a particular gene and contains information about two binding sites, two corresponding transcription factors and experiments confirming cooperative action between transcription factors. The COMPEL database, equipped with the search and browse tools, is available at http://www.gene-regulation.com/pub/databases.html#transcompel. Moreover, we have developed the program CATCH(TM) for searching potential CEs in DNA sequences. It is freely available as CompelPatternSearch at http://compel.bionet.nsc.ru/FunSite/CompelPatternSearch.html.