Bacterial translational control at atomic resolution.
Bacterial translational control at atomic resolution.
复制标题
原子分辨率的细菌平移控制。
DOI：
10.1016/s0168-9525(03)00020-9
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
M. Springer
中科院分区：
文献类型：
--
作者：
P. Romby;M. Springer
翻译调节允许蛋白质合成快速适应环境条件。在原核生物中，许多rna结合蛋白的合成受到翻译反馈机制的调控，该机制涉及它们的天然底物和它们在mRNA上的结合位点之间的竞争，它们通常被认为是彼此相似的。本文描述了苏酰trna合成酶的情况，该合成酶抑制其自身mRNA的翻译。最近的数据提供了第一次在原子水平上描述这种酶识别trnathrd及其在mRNA中的调节位点之间的模仿程度和极限的机会。这些数据也为合成酶与mRNA的结合如何抑制翻译提供了一些线索。
Translational regulation allows rapid adaptation of protein synthesis to environmental conditions. In prokaryotes, the synthesis of many RNA-binding proteins is regulated by a translational feedback mechanism involving a competition between their natural substrate and their binding site on mRNA, which are often thought to resemble each other. This article describes the case of threonyl-tRNA synthetase, which represses the translation of its own mRNA. Recent data provide the first opportunity to describe at the atomic level both the extent and the limit of mimicry between the way this enzyme recognizes tRNAThrand its regulatory site in mRNA. The data also give some clues about how the binding of the synthetase to its mRNA inhibits translation.
DOI：
10.1016/s0021-9258(19)36568-8
发表时间：
1993-09
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
M. Dabeva;J. R. Warner
通讯作者：
M. Dabeva;J. R. Warner