Long-term survival in patients with malignant astrocytoma.
Long-term survival in patients with malignant astrocytoma.
复制标题
恶性星形细胞瘤患者的长期生存。
作者：
M. Salcman;Herman Scholtz;R. Kaplan;Susan Kulik
从1978年至1988年，314例恶性星形细胞瘤的治疗，我们的神经肿瘤小组。由于缺乏足够的随访、肿瘤位于脑干或年龄低于18岁，25名患者被排除在进一步分析之外。在有效研究组剩余的289例患者中，213例为IV级肿瘤（73.7%），76例为III级肿瘤; 167例患者为男性（57.8%），112例为女性，89例患者年龄小于40岁（30.8%）。该系列中有58名长期幸存者（> 36个月）（20%）。长期存活者更有可能小于40岁（x = 41.8; P < 0.005），再次手术者（x = 17.3; P < 0.005），接受过超过60戈伊的放射治疗（x = 11.6; P < 0.005）、具有III级肿瘤（x = 10.6; P < 0.005）和接受过亚硝基脲（x = 6.09; P < 0.02）。性别和血型与长期生存率均无显著相关性。再次手术的患者更可能小于40岁（x = 5.72; P < 0.02），但性别和组织学检查结果与再次手术无关。对于整个系列，观察到的5年生存率为6%。我们的结论是，积极的多学科方法可以产生相当数量的长期生存的恶性星形细胞瘤患者具有良好的预后因素。
From 1978 to 1988, 314 patients with malignant astrocytoma were treated by our neuro-oncology team. Twenty-five patients were excluded from further analysis because of a lack of adequate follow-up, the brain-stem location of the tumor, or an age of less than 18 years. Of the 289 remaining patients in the valid study group, 213 had Grade IV tumors (73.7%) and 76 had Grade III tumors; 167 patients were male (57.8%) and 112 were female, and 89 were less than 40 years of age (30.8%). There were 58 long-term survivors (> 36 mo) in the series (20%). Long-term survivors were much more likely to be less than 40 years of age (x = 41.8; P < 0.005), to have undergone repeated surgery (x = 17.3; P < 0.005), to have received more than 60 Gy of radiation (x = 11.6; P < 0.005), to have Grade III tumors (x = 10.6; P < 0.005), and to have received nitrosoureas (x = 6.09; P < 0.02). Neither sex nor blood type were significantly associated with long-term survival. Patients undergoing repeated surgery were more likely to be less than 40 years of age (x = 5.72; P < 0.02), but neither sex nor histological findings was associated with repeated surgery. For the series as a whole, the observed 5-year survival rate was 6%. We conclude that an aggressive multidisciplinary approach can produce sizable numbers of long-term survivors in malignant astrocytoma patients with favorable prognostic factors.
影响因子：
4.8
作者：
HARSH, GR;LEVIN, VA;WILSON, CB
通讯作者：
WILSON, CB