The management of osteoarthritis in the obese patient: practical considerations and guidelines for therapy
The management of osteoarthritis in the obese patient: practical considerations and guidelines for therapy
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DOI：
10.1111/j.1467-789x.2006.00252.x
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发表时间：
2006-11-01
期刊：
影响因子：
8.9
通讯作者：
Christensen, R.
中科院分区：
文献类型：
--
作者：
Bliddal, H.;Christensen, R.
肥胖和骨关节炎（OA）在越来越多的人群中共存。这两种疾病在几个方面互相影响。人口的演变表明，随着一般年龄和体重的增加，两者都有恶化的趋势。这两种疾病有共同的发病特点，一种疾病的发展会增加另一种疾病的风险，可能是恶性循环的开始。这两种疾病的治疗也有联系。现在有确凿的（黄金）证据表明，通过有效治疗合并OA的肥胖患者，功能状态得到显着改善;短期结果与关节置换术相同。减肥的长期效果仍有待证实。OA绝对是许多疾病之一，其中肥胖必须认真考虑时，规划正确的治疗患者。对这些患者的对照研究中使用的方案进行了审查，可以得出结论，肥胖OA患者的饮食干预的实际方面与一般建议没有不同。
Obesity and osteoarthritis (OA) co-exist in an increasing part of the population. The two diseases intertwine in several ways. The evolution in the population shows a tendency towards deterioration of both by increasing general age and weight. The two diseases share pathogenetic features and the development of one disease increases the risk of the other and may be the onset of a vicious circle. There is a link between treatments of these two diseases as well. There is now solid (gold) evidence that by treating effectively the obesity of patients with co-occurring OA, the functional status is dramatically ameliorated; the short-term results are equal to that of a joint replacement. The long-term efficacy of a weight loss remains to be shown. OA is definitely one of many diseases in which obesity must be taken seriously into account when planning a correct treatment of patients. The regimens used in the controlled studies of such patients are reviewed and it may be concluded that practical aspects of the dietary intervention in obese patients with OA are not different from general recommendations.