A predictive score for retinopathy of prematurity in very low birth weight preterm infants
A predictive score for retinopathy of prematurity in very low birth weight preterm infants
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DOI：
10.1038/eye.2011.334
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发表时间：
2012-03-01
期刊：
影响因子：
3.9
通讯作者：
Procianoy, R. S.
中科院分区：
文献类型：
--
作者：
Eckert, G. U.;Fortes Filho, J. B.;Procianoy, R. S.
目的本研究描述了基于累积危险因素预测严重早产儿视网膜病变（ROP）评分的发展，将评分与出生体重（BW）和胎龄（GA）进行比较，以预测ROP的发病。方法对BWp1500 g和/或GAp32周的早产儿进行前瞻性队列研究。该评分是根据新生儿体重、总体重、出生至6周的体重比例增加、机械通气时的氧气使用以及出生至6周的输血需求来制定的。考虑各变量对任何阶段发生和严重ROP的影响，通过线性回归建立评分。采用受试者工作特征（ROC）曲线确定该评分的最佳灵敏度和特异性值。所有变量都输入到Excel电子表格（Microsoft）中，供眼科医生在筛查期间实际使用。结果共纳入474例患者。ROC曲线下面积分别为0.77和0.88，用于预测任何阶段和严重ROP。当单独测量时，这些值显著高于体重（0.71）和平均体重（0.69）。结论ROPScore是一种很好的新生儿ROP危险因素指标，记录简便，比BW和GA更准确地预测了早产儿任何阶段ROP或重度ROP。该评分系统非常简单，眼科医生在进行ROP筛查检查时可以常规使用。中国眼科杂志（2012）26,400-406；doi: 10.1038 /眼睛。2011.334;2011年12月23日在线发布
Aims This study describes the development of a score based on cumulative risk factors for the prediction of severe retinopathy of prematurity (ROP) comparing the performance of the score against the birth weight (BW) and gestational age (GA) in order to predict the onset of ROP.Methods A prospective cohort of preterm infants with BWp1500 g and/or GAp32 weeks was studied. The score was developed based on BW, GA, proportional weight gain from birth to the 6th week of life, use of oxygen in mechanical ventilation, and need for blood transfusions from birth to the 6th week of life. The score was established after linear regression, considering the impact of each variable on the occurrences of any stage and severe ROP. Receiver operating characteristic (ROC) curves were used to determine the best sensitivity and specificity values for the score. All variables were entered into an Excel spreadsheet (Microsoft) for practical use by ophthalmologists during screening sessions.Results The sample included 474 patients. The area under the ROC curve for the score was 0.77 and 0.88 to predict any stage and severe ROP, respectively. These values were significantly higher for the score than for BW (0.71) and GA (0.69) when measured separately.Conclusions ROPScore is an excellent index of neonatal risk factors for ROP, which is easy to record and more accurate than BW and GA to predict any stage ROP or severe ROP in preterm infants. The scoring system is simple enough to be routinely used by ophthalmologists during screening examination for detection of ROP. Eye (2012) 26, 400-406; doi: 10.1038/eye. 2011.334; published online 23 December 2011