Lymphoproliferative disorders of the T-cell series. A review.
Lymphoproliferative disorders of the T-cell series. A review.
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T 细胞系列的淋巴增殖性疾病。
DOI：
10.1097/00005792-198009000-00002
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发表时间：
1980
期刊：
影响因子：
1.6
通讯作者：
Good,RA
中科院分区：
文献类型：
--
作者：
Safai,B;Good,RA
近年来，人们对淋巴系恶性肿瘤的认识有了很大的提高。这一改进在一定程度上源于新技术的广泛应用，这些技术允许精确定义淋巴样细胞的数量(86,112)。这些方法中最有用的包括细胞表面标记和对恶性细胞的酶分析，以及与正常淋巴细胞的群体和亚群的调查相关的广泛研究。在淋巴系统恶性肿瘤中，T细胞型比B细胞型受到的关注更少。本综述的目的是考虑T细胞淋巴瘤的临床特征、组织学特征、免疫病理性质以及对治疗的反应。对淋巴系恶性肿瘤的新观点的冲动源于对免疫系统的两个主要武器的定义(66)。现在清楚的是，淋巴系统恶性肿瘤可以清楚地被视为代表单克隆性恶性表达，在这种情况下，细胞通常可以被认为是冻结在淋巴样细胞的两个主要分支中的一个或另一个内的几个分化阶段中的一个。可以预见，对于T细胞淋巴瘤，就像其他淋巴系统恶性肿瘤一样，治疗最终将直接与参与恶性过程的细胞的性质有关。因此，改进定义和制定适当的分类最终将产生实际影响。淋巴瘤的治疗已经与这些疾病的新分类有关，这一问题将在本分析中予以强调。
Recent years have witnessed a major improvement in understanding of the lymphoid malignancies. This improvement has derived in part from extensive employment of new techniques which permit precise definition of the population of lymphoid cells (86, 112). The most useful of these methods include cell surface marker and enzymatic analyses of the malignant cells, and the extensive studies relating these analyses to investigations of the populations and subpopulations of normal lymphocytes. Among the lymphoid malignancies, those of T-cell type have received less attention than those of B-cell class. It is the purpose of this review to consider the clinical characteristics, histologic features, and immunopathologic nature of the T-cell lymphomas, and their responses to therapy. The impulse for a new view of the lymphoid malignancies originated from the definition of the two major arms of the immunity system (66). It is now clear that the lymphoid malignancies can incisively be viewed as representing monoclonal malignant expressions in which the cells can often be considered to be frozen at one of the several stages of differentiation within one or the other of two major branches of lymphoid cells. It is to be anticipated for the T-cell lymphomas, as for each of the other lymphoid malignancies, that treatment will ultimately be related directly to the nature of the cells involved in the malignant process. Thus, improvement in definition and development of appropriate classifications will ultimately have pragmatic impact. Already, treatment of the lymphomas has been related to the new classifica-tions of these diseases and this issue will be ad-dressed in this analysis.