Memory impairment in schizophrenia: a study using event-related potentials in implicit and explicit tasks
Memory impairment in schizophrenia: a study using event-related potentials in implicit and explicit tasks
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DOI：
10.1016/s0165-1781(01)00305-5
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发表时间：
2001-11-01
影响因子：
11.3
通讯作者：
Debruille, JB
中科院分区：
文献类型：
--
作者：
Guillem, F;Bicu, M;Debruille, JB
尽管记忆障碍被认为是精神分裂症的一个主要因素，但只有少数研究通过专门设计的事件相关电位（ERP）方案来研究记忆障碍。在这项研究中，记录了 15 名精神分裂症患者和 15 名匹配的对照受试者在执行对陌生面孔的内隐和外显记忆任务时的 ERP。结果表明，患者在隐性和显性任务中对 N400 样成分的调节均减少，这表明传入信息与个人知识的整合不足。患者还在显性任务中表现出增强的额部分布活动，这可能代表内在上下文信息整合的损害、抑制主动干扰的能力的紊乱或这两个过程的组合。最后，在隐性和显性任务中，晚期阳性成分的调节与对照受试者的调节没有差异，这表明精神分裂症中所暗示的助记结合过程的损伤是更定性的，即由于先行过程的异常而导致的不完整或不适当。观察到的 ERP 调节损伤与症状之间的相关性进一步支持了这些解释。 (C) 2001 Elsevier Science Ireland Ltd. 保留所有权利。
Although memory impairment is recognized as a major fact of schizophrenia, only a few studies have investigated memory impairments with specifically designed event-related potential (ERP) protocols. In this study, ERPs were recorded from 15 schizophrenia patients and 15 matched control subjects during implicit and explicit memory tasks for unfamiliar faces. The results showed that patients have a reduced modulation of an N400-like component in both the implicit and explicit tasks that suggests a deficient integration of incoming information with personal knowledge. Patients also displayed an enhanced frontally distributed activity in the explicit task that may represent an impairment in the integration of intrinsic contextual information, a disturbance in the ability to inhibit proactive interference or a combination of both processes. Finally, the modulation of the late positive component did not differ from that in control subjects in both implicit and explicit tasks, suggesting that the impairment in mnemonic binding processes suggested in schizophrenia is more qualitative, i.e. incomplete or inappropriate, due to the anomalies in antecedent processes. The correlations observed between impairments of ERP modulation and symptoms further support these interpretations. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.