Lower maximum standardized uptake value of fluorine-18 fluorodeoxyglucose positron emission tomography coupled with computed tomography imaging in pancreatic ductal adenocarcinoma patients with diabetes
Lower maximum standardized uptake value of fluorine-18 fluorodeoxyglucose positron emission tomography coupled with computed tomography imaging in pancreatic ductal adenocarcinoma patients with diabetes
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DOI：
10.1016/j.amjsurg.2014.06.038
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发表时间：
2015-04-01
影响因子：
3
通讯作者：
Hwang, Jin-Hyeok
中科院分区：
文献类型：
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作者：
Chung, Kwang Hyun;Park, Joo Kyung;Hwang, Jin-Hyeok
背景：糖尿病(DM)对氟-18-脱氧葡萄糖正电子发射断层扫描(F-18-FDG PET/CT)诊断胰腺导管腺癌(PDAC)敏感性的影响尚不清楚。本研究旨在评价糖尿病对F-18-FDG PET/CT诊断PDAC的影响。方法：共173例接受F-18-FDG PET/CT检查的PDAC患者入选，其中DM组75例，非DM组98例。结果：糖尿病组的最大标准摄取值(SUVmax)显著低于非糖尿病组(4.403比5.998，P=.001)。糖尿病组的SUVmax(临界值为4.0)显著低于非糖尿病组(49.3%比75.5%，P<0.01)，正常血糖的糖尿病组(n=24)也低于非糖尿病组(54.2%比75.5%，P=0.038)。结论：糖尿病是糖尿病患者F-18-FDG PET/CT的SUVmax降低的原因之一。(C)2015 Elsevier Inc.保留所有权利。
BACKGROUND: The effects of diabetes mellitus (DM) on sensitivity of fluorine-18 fluorodeoxyglucose positron emission tomography coupled with computed tomography ( F-18-FDG PET/CT) for diagnosing pancreatic ductal adenocarcinomas (PDACs) is not well known. This study was aimed to evaluate the effects of DM on the validity of F-18-FDG PET/CT in PDAC.METHODS: A total of 173 patients with PDACs who underwent F-18-FDG PET/CT were enrolled (75 in the DM group and 98 in the non-DM group). The maximum standardized uptake values (SUVs(max)) were compared.RESULTS: The mean SUVmax was significantly lower in the DM group than in the non-DM group (4.403 vs 5.998, P = .001). The sensitivity of SUVmax (cut-off value 4.0) was significantly lower in the DM group than in the non-DM group (49.3% vs 75.5%, P < .001) and also lower in normoglycemic DM patients (n = 24) than in non-DM patients (54.2% vs 75.5%, P = .038).CONCLUSION: DM contributes to a lower SUVmax of F-18-FDG PET/CT in patients with PDACs. (C) 2015 Elsevier Inc. All rights reserved.